International Mammalian Genome Society

The 14th International Mouse Genome Conference (2000)


A2. Y sequence

A. I. Agoulnik1, H. L. Boettger-Tong1, J. Rohozinski1, M.J. Mitchell2, C. E. Bishop1,3
1Baylor College of Medicine, Depts. Ob/Gyn,
2INSERM Unite 491, Unite de Genetique Medicale et Developpement, Faculte de Medecine, Marseille, France.
3Molecular and Human Genetics, Houston, TX, 77030, USA,

We have assembled a complete BAC contig of the Sxr region of the mouse Yp chromosome (http://www.hgsc.bcm.tmc.edu/seq_data/maps/mouse/Yp.gif). The Human Genome Sequencing Center of Baylor College of Medicine begun sequencing of the minimal tiling path of the region. The acquisition of a full genome sequence provides the basis for gene identification, genome organization, analysis of promoters and gene regulation. Through comparisons with available mouse X chromosomal data and interspecies comparisons of the sequences with homologous regions of the human Y and X chromosomes the evolutionary history of the sex chromosomes in mammals can be analyzed. All these analyses will be presented as well as complete annotation of the Yp sequence.


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