International Mammalian Genome Society

The 14th International Mouse Genome Conference (2000)

B26. A Missense Mutation of the Melanocortin 1 Receptor Gene Carried by a New Inbred Strain MSKR Derived from Mus musculus molossinus

A. Wada, T. Kunieda1, M. Nishimura2, Y. Kakizoe-Ishida, M. Okumoto3 and M. Tsudzuki4
Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Japan
1Graduate School of Natural Science and Technology, Okayama University, Japan
2Institute of Laboratory Animals, Graduate School of Medicine, Nagoya University, Japan
3Department of Applied Bioscience, Research Institute of Advanced Science and Technology, Osaka Prefecture University, Japan
4Department of Animal Science, Faculty of Applied Biological Science, Hiroshima University, Japan

The MSKR inbred strain, which is originated from Mus musculus molossinus and has a coat color mutation, was established in April, 1998. The back of the MSKR mice is light yellowish brown, although the belly and eyes of the mice are white and black as usually seen in wild-type molossinus mice. Individual mutant hairs show so-called agouti pattern, but the yellow band is greatly lengthened. We named this coat-color trait "tawny" based on the dorsalcoloration. The tawny trait is an autosomal recessive and its gene is located at the distal region on Chromosome 8. The tawny mutant gene is a new allele at the Mc1r locus and dominant to the recessive yellow (Mc1re). The proposed gene symbol for the tawny is Mc1rtaw. The transcript of the Mc1rtaw gene has three amino acid substitutions (i.e., 101 valine to alanine, 216 valine to alanine, 252 tryptophan to cysteine). The third substitution is considered to be responsible for the expression of the tawny coat color, because the first and second substitutions exist in non-tawny colored mice, whereas the 252 tryptophan to cysteine substitution exists in only tawny-colored mice. Gene frequency of the Mc1rtaw is 3.25 % in wild M. m. molossinus population inhabiting Sakai City, Osaka Prefecture, Japan, where the original mice of the MSKR strain were captured.

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