International Mammalian Genome Society

The 14th International Mouse Genome Conference (2000)

C7. Rat Genome Database: A Platform for Rat, Mouse and Human Comparative Genomics

Peter J. Tonellato1, Jian Lu1, Deying Chen1, Haiping Xia1, Zhitao Wang1, Anne Kwitek-Black2, Dean Pasko1, Peter Long1, Mary Shimoyama1, Jessica Ginster1, Janan Eppig3, Donna Maglott4, Greg Schuler4, Fredrik Stahl5, Goran Levan5, Simon Twigger1 and Howard Jacob2
1Bioinformatics Research Center, and
Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA;
The Jackson Laboratory, Bar Harbor, Maine 04609, USA;
National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA.
CMB - Genetics Lundberg Laboratory, Goteborg University, GOTEBORG, Sweden.

The Rat Genome Database's (RGD) stated mission is "to collect, consolidate, and integrate data generated from ongoing rat genetic and genomic research efforts and make these data widely available to the scientific community." In collaboration with the Medical College of Wisconsin, The Jackson Laboratory, National Center for Biotechnology and Information (NCBI), and the Genetics Lundberg Laboratory (Gothenburg, Sweden) have created a RGD to meet these aims. The primary focus of RGD is to aid researchers who use the rat as a model organism for human disease. To support these studies we have integrated genetic and genomic resources in RGD that are continually expanded through ongoing data and literature curation. One of our prime goals is to incorporate QTL data to facilitate physiological genomics studies relating disease with the genome. A complimentary goal is the development resources providing comparative information and maps between rat, mouse and human, which will facilitate the application of results in one species to experiments in another species. In collaboration with the Mouse Genome Database (MGD) and NCBI, close links are being created between RGD and MGD, LocusLink, RefSeq, UniGene and related external databases to improve access to relevant data. In addition, a dynamic sequence-based homology environment is under development to enable rat, mouse and human researchers to view mapped genes and sequences and their locations with respect to conserved regions in all three organisms. To support its other aims, RGD has a variety of tools available for the researcher, equally useful to researchers working in the rat as well as other organisms. A sampling of these tools will be presented. Thus, RGD is not only a valuable resource for those working with the rat model but also for investigators who focus on other model organisms, but wish to harness the existing genetic and physiological data available in the rat to complement their own work.

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