International Mammalian Genome Society

The 15th International Mouse Genome Conference (2001)


Dr. Martin Hrabé de Angelis
Institute of Experimental Genetics
GSF-National Research Center for Environment and Health
Ingolstädter Landstrasse 1
Munich D-85764 Neuherberg Germany

Co-Authors: 1)Tocchini-Valentini G, 2)Ryffel B, 3)Brown S, 4)Ährlund-Richter L, 5)Gulbenkian S, 6)Cameron G
Institutions: 1)Conseglio Nazionale delle Ricerche (CNR), European Mouse Mutant Archive, 2)Centre National de la Recherché Scientifique (CNRS), Centre de Developpement des Techniques Avancees pour l'Experimentation Animale (CDTA), 3)Medical Research Council (MRC), Mammalian Genetic Unit (MGU), 4) Karolinska Institutet, Clinical Research Center, Unit for Embryology and Genetics, 5) Fondação C. Gulbenkian, Instituto Gulbenkian de Ciencia, 6)European Molecular Biology Laboratory, The European Bioinformatics Institute (EBI)

A rapidly growing number of mouse mutant lines is produced for the characterisation of inherited diseases. The establishment of a world–wide network of repositories for all generated mutant lines is essential to make them available to the scientific community. Many valuable mutant lines would be lost due to the constraints of space and finance in many laboratories. EMMA, the European Mouse Mutant Archive, represents the European part of this world–wide network of repositories. Therefore the work of EMMA represents a crucial element in achieving tremendous benefits for human health inherent in current genetic research.

EMMA currently develops towards the central European repository for storing of mouse mutant strains via cryopreservation and the maintenance of mouse mutant databases. EMMA makes valuable mouse models available to investigators and is presently setting up a service for germ–free breeding. Applications for depositing and requesting mutant strains can be submitted through the EMMA website ( or by e–mail ( EMMA actively co–operates with “The Jackson Laboratory”, USA, and other primary repository resources world–wide.  Primary public research institutions of the participating countries support EMMA and it has obtained support by the European Commission.

The EMMA consortium consists of the centre facility at CNR (Monterotondo, Italy) and partners at CNRS (Orleans, France), MRC (Harwell, UK), Karolinska Institute (Stockholm, Sweden), Gulbenkian Institute (Oreias, Portugal), HSF/GSF (Munich, Germany) and EBI/EMBL (Hinxton, UK). EMMA was initiated under the highest quality standards and was opened to the public in 1999.   The new director of the EMMA consortium is Martin Hrabé de Angelis, who was announced by the internationally constituted Project Policy Committee (IPPC). Present Chairmen of the IPPC are: P. Gruss, Göttingen and P. Rigby, London.

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