International Mammalian Genome Society

The 15th International Mouse Genome Conference (2001)


POSTER 193 -  HIGH RESOLUTION MAPPING REVEALS TWELVE MOUSE AND FIVE HUMAN NEW GENE LOCATIONS AND AN INVERSION BETWEEN MOUSE AND MAN ON CHROMOSOMES 11/2p13-14

Mrs Sonja Fuchs
University of Bielefeld
Universitätsstrasse 25
Bielefeld
33615
Germany

Co-Authors: 1) Resch K, 1) Thiel C, 2) Platzer M, 1) Jockusch H, 1) Schmitt-John T
Institutions: 1) Developmental Biology and Molecular Pathology, University of Bielefeld, 2) Dept. of Genome Analysis, IMB

During the analysis of the region of the neurologic mouse mutation wobbler (wr), high resolution physical maps of proximal mouse Chromosome 11 and the homologous region on human Chromosome 2p13-15 were established. By human EST analysis and sequencing of mouse BACs we determined locations of eleven mouse genes/cDNAs and two more were located by radiation hybrid mapping. The gene Otx1 and the cDNAs Kiaa0903, Caco2, M13, Peli1, Hcc8, Ugp2 were sequenced.

Extending the annotation data of the human draft sequence, the human genes OTX1 and the cDNAs KIAA0903, CACO2, KIAA0582 and FLJ21950 were localized within the corresponding region on chromosome 2p13-15. Whereas the close proximity of all 23 analyzed genes is conserved between mouse and man gene order is disrupted by an 1 Mb inversion.


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