International Mammalian Genome Society

The 15th International Mouse Genome Conference (2001)


POSTER 195 - UK MOUSE SEQUENCING CONSORTIUM: CHROMOSOME 2 AND 4 PROJECTS

Dr Philippe Gautier
MRC Human Genetics Unit
Western General Hospital
Crewe Road
Edinburgh
EH4 2XU
United Kingdom

Co-Authors:1) MRM Botcherby, 1) D Clarke, 1) G Elgar, 1) S Warner, 1) D Goode, 4) S Cross, 3) P Denny, 5) H Hummerich, 6) W Miller, 1) J Greystrong,1)L Greenham, 1) M Campbell, 1) S Jones, 1) N Leaves, 1) S Manjunath, 1) G Strachan, 1) E Boal, 1) G Hunter, 1) C Kimberley, 1) P North, 1) R Connor, 1) P Weston, 1) L Cave-Berr1, 2) S Simms, 2) L Mathews, 2) O McCann, 2) T Hubbard, 2) R Durbin,  3) M Cadman, 3) R McKeone, 3) C Sellick, 3) M Strivens, 3) AM Mallon, 3) V Proutski, 5) M Iravani, 4) I Smyth, 4) S White, 4) R Edgar,4)V van Heyningen, 5) P Little, 4) I Jackson, 2) J Rogers, 1) RD Campbell and 3) SDM Brown
Institution: 1) HGMP Resource Centre, Hinxton Genome Campus 2) Sanger Centre, Hinxton Genome Campus, 3) MRC UK Mouse Genome Centre and Mammalian Genetics Unit, 4) MRC Human Genetics Unit, Western General Hospital, 5) Imperial College, Exhibition Road, South Kensington, 6) Dept of Computer Science, The Pennsylvania State University

The UK Mouse Sequencing Consortium is a collaboration between the MRC Human Genetics Unit (Edinburgh), Imperial College (London), the MRC Mouse Genome Centre (Harwell), the HGMP Resource Centre and the Sanger Centre.

It aims to underpin the UK mouse genetics effort by providing finished sequence for four targeted regions, covering 40 to 50 MB,  that are currently the focus of intense genetic study. Furthermore, 10% of the sequencing capacity will be devoted to additional requested by UK genomics researchers.

The Harwell group (mapping), in collaboration with the Sanger Centre (sequencing), is focusing on two regions on chromosome 13 and chromosome X. Our group (MRC-HGU) in Edinburgh is focusing on two regions on chromosomes 2 and 4. The chromosome 2 region is syntenic of Human 11p13-14 and the chromosome 4 region is synthetic to Human 9p23 and 9q33. The mapping of these regions is done at HGU-MRC in collaboration with Imperial College who do the clones fingerprinting and with the HGMP who do the sequencing.

Both these regions are covered extensively by sets of overlapping deletions, and are also the targets for 2 ENU mutagenesis projects carried out at MRC-Harwell (chromosome 2) and at Baylor College of Medicine, Houston, Texas (chromosome 4). The comparison mouse/human shows highly conserved sequences outside coding regions, which are new potential control elements. These results have already sparked new projects in several groups in the Unit.


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