International Mammalian Genome Society

The 15th International Mouse Genome Conference (2001)


POSTER 25 - AGE-DEPENDENT QUANTITATIVE TRAIT LOCI AFFECTING BODY WEIGHT IN A CROSS BETWEEN MOUSE LINES NMRI AND DBA/2

Mr. Ersin Karatayli
Research Institute for the Biology of Farm Animals
Dept of Molecular Biology
Wilhelm-Stahl-Allee 2
Dummerstorf 18196
Germany

Co-Authors: Renne U, Karle S, Brockmann GA
Institutions: Reserach Institute for the Biology of Farm Animals

QTLs influencing body weight at the age of 2, 3, 4, 5, and 6 weeks were mapped by linkage analysis in a cross between the growth selected mouse line NMRI and the control line DBA/2. In addition to body weight, QTLs influencing abdominal fat weight and muscle weight were mapped at the age of 6 weeks. The two lines differ in body weight by 115% at the age of 42 days. Linkage analysis was performed to detect age-dependent QTLs responsible for growth differences between NMRI and DBA/2 in a structured F2 pedigree. Genome-wide significant QTL effects were mapped for body weight in at least one of the ages on chromosomes 1, 2, 3, 4, 7, 9, and 14. A shift in the effects of QTLs was observed depending on the age of the animals. The effects found for all QTLs affecting body weight on different ages were mostly additive, accounting together for 35-45 % of the phenotypic variance of body weight within the corresponding F2 population. The QTLs affecting body weight coincide with QTLs for abdominal fat weight on chromosomes 1, 2, 7, 14 and with QTLs for muscle weight on chromosomes 1, 7, and 14. The information on the age-dependent QTL effects is useful for the identification of the underlying genes.


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