International Mammalian Genome Society

The 15th International Mouse Genome Conference (2001)


POSTER 137 - BIOINFORMATICS ON MOUSE MUTAGENESIS FOR DEVELOPMENTAL DEFECTS

Dr. Bin Liu
Baylor College of Medicine
One Baylor Plaza S409A
Houston, TX 77030
USA

Co-Authors: Monica Justice
Institutions: Department of Molecular and Human Genetics, Baylor College of Medicine

Mouse Mutagenesis for Developmental Defects project utilizes ENU as a powerful mutagen in mouse spermatogonial stem cells. By determining the function of genes on a mouse chromosome, we can extrapolate to predict function on a human chromosome. Many of the new mutants are expected to represent models of human diseases such as birth defects, patterning defects, growth and endocrine defects, neurological anomalies, and blood defects. The goals of the bioinformatics group are: designing the database to organize the data produced in this project, presenting these data on the website for public access, designing internal web site for mouse handling and data collecting and developing computer programs for data analysis. On the public website, the information of ENU mutants can be accessed through the mouse mutant resources and mutants can be requested if they are available. And we provide the Email alert for the notice of the new mutants to our registered users. This feature is expected to particularly benefit our mouse community. On the internal website, we provide a convenient data entry site and a virtual mouse facility that utilizes a barcode system. Any activities of either the mouse handling or the data collecting will be recorded into the database through the virtual mouse facility website. This system is expected to greatly help organize data and avoid many human errors. For more detail information, please visit our web site: http://www.mouse-genome.bcm.tmc.edu


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Last modified: Saturday, November 3, 2012