International Mammalian Genome Society

The 15th International Mouse Genome Conference (2001)


POSTER 141 - THE BIOKNOWLEDGE LIBRARY: BRINGING BIOLOGY TO GENOMICS AND PROTEOMICS

Dr Kathy O'Neill
Bioinformatics
Proteome Division, Incyte Genomics
100 Cummings Center, Suite 435M
Beverly
MA 01915
USA

Co-Authors: J Brooks, J Garrels Proteome Division, Incyte Genomics

With the completion of the human genome sequence, Proteomes BioKnowledge Library provides a unique resource for comparative genomic studies, interpretation of functional genomics or proteomic datasets and disease and pathway studies.  Using sequenced genomes as frameworks, our expert, Ph.D. curators collect protein knowledge currently scattered throughout the literature, and put it into a concise format.  The information is available on-line in a highly navigable format.

The Human Proteome Survey Database (HumanPSD) is one component of the BioKnowledge Library, and contains up-to-date information for over 12,000 known human proteins, 6,000 mouse proteins, and 3,000 rat proteins.  Proteins are described by their biochemical functions, cellular and organismal roles, subcellular locations and expression patterns.  Mouse proteins are additionally described by their mutant phenotypes, which were captured from over 9000 references.  An additional mammalian database, GPCR-PD, provides in-depth information for an important class of drug target proteins, G-protein coupled receptors, and for their downstream signaling molecules.  Both mammalian databases are fully integrated with Proteomes model organism databases for S.cerevisiae (YPD), S.pombe (PombePD), C.elegans (WormPD) and pathogenic fungi (MycoPathPD) proteins.

The model organism volumes are freely available to academic researchers (wwww.proteome.com).


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Last modified: Saturday, November 3, 2012