International Mammalian Genome Society

The 15th International Mouse Genome Conference (2001)


MOUSE INFERTILITY AND GENOME INSTABILITY MUTANTS

John Schimenti
The Jackson Laboratory
600 Main St.
Bar Harbor, ME 04609 USA

Co-Authors: Libby B, Ward J, Munroe R, Shima N, Bergstrom R
Institutions: The Jackson Laboratory

Mutations affecting gametogenesis and DNA repair were isolated by mutagenesis of mice and ES cells. The germ cell mutations affect stem cell development, meiosis and spermiogenesis. We have also employed a novel, high throughput screen to detect potentially cancer susceptible mice. This involves a flow cytometric assay to detect genome instability. We will present the paradigm and concentrate on one particular mutant that appears to be defective in double strand break repair.


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