International Mammalian Genome Society

The 15th International Mouse Genome Conference (2001)

POSTER 145 - Genome Database (RGD) mapping disease onto the Genome

Simon Twigger
Bioinformatics Research Center
Medical College of Wisconsin

Co-Authors: 1)Simon Twigger, 1)Jian Lu, 1)Mary Shimoyama, 1)Dan Chen, 1)Dean Pasko, 1)Hanping Long, 1)Jessica Ginster, 1)Chin-Fu Chen, 1)Rajni Nigam, 2)Anne Kwitek-Black, 3)Janan Eppig, 3)Lois Maltais, 4)Donna Maglott, 4)Greg Schuler, 2)Howard Jacob and 1)Peter Tonellato.
Institutions: 1) Bioinformatics Research Center, and 2) Human and Molecular Genetics Center, Medical College of Wisconsin, 3) The Jackson Laboratory, Bar Harbor, 4) National Center for Biotechnology Information, NIH

The Rat Genome Database (RGD, is a disease centric resource of comprehensive curated data and information from rat genetic and genomic research. The primary focus of RGD is to provide the information that will aid researchers in their use of the rat as a model organism of human disease. To support this, genetic and genomic resources are constantly added to RGD through literature and bulk dataset curation. RGD includes data on genes, quantitative trait loci (QTL), microsatellite markers and strains used in genetic and genomic research. A new tool, VCMap, is a dynamic sequence-based homology tool that allows, researchers to view mapped genes and sequences and their locations in Rat, Mouse and Human. RGD also provides tools for gene prediction, radiation hybrid mapping, polymorphic and marker selection. Future developments include the introduction of curated data related to common diseases studied in the rat. This data will be integrated with the emerging rat genomic sequence and annotation pipelines to provide a disease-centric resource, applicable to human and mouse via tools such as VCMap. RGD also offers a Visiting Scientist program and web- based Rat Community Forum, a forum for rat researchers and others interested in the rat as an experimental model. RGD is a valuable resource for those working with the rat, and other model organisms who wish to harness rat genetic and physiological data.

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Last modified: Saturday, November 3, 2012