International Mammalian Genome Society

The 15th International Mouse Genome Conference (2001)


POSTER 182 - IDENTIFICATION AND MAPPING OF Prmt3 AND Tip30, TWO GENES ON PROXIMAL MOUSE CHROMOSOME 7

Dr. Lisa Webb
The Jackson Laboratory
600 Main Street
Bar Harbor
MA 04609
USA

Co-Authors: 1)Dhar M, 2)Hauser L, 1)Culiat C, 2)Johnson D
Institutions: The University of Tennessee, Graduate School of Genome Science & Technology, Oak Ridge National Laboratory

Sequence analysis of BACs selected as part of our effort to coordinate transcript and mutation maps of a 4-6 cM region surrounding the pink-eyed dilution (p) deletion complex of mouse chromosome 7 has identified two genes, Protein arginine methyltransferase 3 (Prmt3) and Tat-interacting protein, 30 kDa (Tip30).  Tip30 is a transcription factor involved in metastasis and HIV-1 infection.  The functional role of Prmt3 is under investigation.  These genes are located approximately 5 kb apart on a single 150 kb BAC that maps completely within an interval delimited by the proximal breakpoints of two deletions.  We describe the genomic structure of these two genes and their expression profiles in the mouse, and we present the fine-structure mapping data that places them within the p-deletion interval that also contains two ENU-induced alleles of a gene responsible for a lethal epilepsy phenotype.


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