International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 10 - Tmevpg1 WHICH CODES FOR A NON CODING mRNA EXPRESSED IN THE IMMUN SYSTEM, IS A CANDIDATE GENE FOR Tmevp3 locus

J-F Bureau
Institut Pasteur

1) Vigneau S, 2) Rohrlich P-S, 1) Brahic M,
1) Unité des Virus Lents (CNRS URA 1930), 2) Unité Immunité Cellulaire Antivirale, 

Tmevp3 locus controls the viral genome load during the persistent infection of mouse central nervous system (CNS) by Theiler's virus. We have identified a candidate gene for this locus, named Tmevpg1, by a positional cloning approach. The murine Tmevpg1 gene and its human ortholog TMEVPG1 are expressed in the immune system and encode what appears to be a non-coding RNA. They are located in cluster of cytokines which includes interferon gamma (Ifng) and one or two homolog of interleukin 10. We now report that Tmevpg1 is expressed in uninfected splenocytes of both resistant B10.S mice and SJL/J mice congenic for Tmevp3 locus of B10.S haplotype but is not detected in the case of susceptible SJL/J mice. A similar pattern of expression has been found in CNS infiltrating immune cells following inoculation by Theiler's virus. Tmevpg1 is down regulated after in vitro stimulation of CD4+ or CD8+ splenocytes whereas Ifng is up regulated. Similar observations were obtained with human NK, CD4+ and CD8+ T lymphocytes for TMEVPG1 and IFNG. Tmevpg1 is a strong candidate gene at Tmevp3 locus and might be involved in the regulation of Ifng expression.


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