International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 100 - THE ĎANONYMUSí LABORATORY INFORMATION MANAGEMENT SYSTEM Ė DESIGNING A MODULE FOR THE REAL TIME CAPTURE OF ANIMAL GENOTYPE AND PHENOTYPE DATA

P Jones
MRC Harwell

1) Brundrett A, 1) Jones J, 1) Oxspring R, 1) Selley R, 1) Seymour M, 2) Johnson R
1) Informatics Group, MRC Harwell, 2) Mary Lyon Centre, MRC Harwell

The Mary Lyon Centre (MLC) is a state-of-the-art central facility for mouse genetic studies being constructed on the MRC Harwell (UK) campus.An important aspect of the LIMS system for the MLC is the ability to allow technicians to record, and logically store, data relating to the genotype and phenotype of animals in their care.† Previous electronic data storage systems implemented at MRC Harwell have used free text to allow users to enter this data.† This approach can make statistical analysis of the data difficult, as there is a lack of standardisation of the data set.The AnonyMus system will employ a relational database structure to allow the storage of a library of mouse genes / alleles and phenotypes. It will be possible to associate these records with the mice in the system as genotypes and phenotypes of interest.† The users will be prompted to record their phenotypic observations throughout the animalís life.† Suitably qualified individuals will be able to record the genotypes of these animals, based upon phenotypic observations, the animalís pedigree and genotype data derived from tissue samples.† The poster will explore the problems associated with the design of such a system, including the need to build in sufficient flexibility to allow the recording of unexpected observations.† Approaches to the problems of recording chromosomal mutations and the data associated with transgenic mice will be considered.† A proposed database structure will be presented together with some prototype forms for use by the technicians and scientists using the system.


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