International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 104 - Frap IS A CANDIDATE GENE FOR THE PLASMACYTOMA SUSCEPTIBILITY/RESISTANCE LOCUS, Pctr2

V Bliskovski
NCI, NIH

1)Ramsay E, 1) Shi W, 1) Scott J, 1) Zhang S, 2) Qian X, 2) Lowy D, 1) Mock B
1) Laboratory of Genetics, CCR, NCI, NIH, 2) Laboratory of Cellular Oncology, CCR, NCI, NIH

Mouse plasmacytomas provide a model for the dissection of complex genetic traits associated with cancer.   The Pctr2 locus resides in the telomeric region of mouse Chr 4, and the resistant DBA/2 allele delays the onset of plasmacytomagenesis in inbred strains of mice.  In the current study, we report the identification of Frap as a candidate gene residing in the appropriate interval for the Pctr2 locus.   The Frap (FKBP12 rapamycin associated protein) gene encodes a kinase capable of phosphorylating many substrates and interacting with a large number of proteins involved in the PI 3-kinase signal transduction pathway, which can be activated by IL6.  We found that Frap may act as a tumor suppressor locus for pristane-induced plasmacytomas by biochemical and biological assays.  Although, studies with other systems have suggested that Frap may foster tumor formation, our functional assays in plasma cells lend credence to the notion that Frap is a candidate for the Pctr2 tumor susceptibilty/resistance locus where it acts as a tumor suppressor.


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