International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 117 - ENU MUTAGENESIS SCREEN FOR PHENOTYPES IMPORTANT IN LIVESTOCK PRODUCTION AND HEALTH

Weber John
University of Nebraska

Hannon K, Schnell G, Meerkatz L, Alberts T.
University of Nebraska, Lincoln

Livestock production and health are impacted by genetic-based differences in size and growth, muscle development, lactation levels, reproductive ability, and disease susceptibility.  Determining which genes control these biological processes will lead to new approaches that have the potential of dramatically improving livestock management and well-being.  Using the mouse as a model, we are taking a phenotype-driven genetics-based approach to identify candidate genes for further study in mammalian livestock species.  A three-generation ENU mutagenesis screen has been initiated using the C57Bl/6 strain to generate mutants with phenotypes of interest.  A progress report will be presented on the number of pedigrees tested, details of the screens employed, and the number and type of mutants generated (both dominant and recessive).


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