International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 129 - INDUCED MUTANT MOUSE MODELS OF HUMAN DISEASE:  THE INDUCED MUTANT RESOURCE AT THE JACKSON LABORATORY

DB Lane
The Jackson Laboratory

Rockwood SF, Mobraaten LE, Davisson MT
The Jackson Laboratory

Genomic and biological similarities between mice and humans and the accumulated knowledge about mouse genetics establish the mouse as the foremost research tool for studying human disease.  Models for studying human disease that are generated by mouse genome manipulation offer an opportunity to dissect complex etiology and an in vivo system for testing detection methods and pharmacological treatments.  Increasing development and use of mouse models requires cooperative resources to preserve and distribute them.  The Induced Mutant Resource (IMR) at The Jackson Laboratory allows the scientific community to access biomedically significant mouse models by collecting and distributing induced mutant mouse strains.  As a centralized repository and resource, the IMR also ensures genetic integrity and protects each strain by cryopreservation.  The IMR offers support to researchers in the form of curated strain information through an online database.  Mutant strain records in the IMR database include information on phenotype description, strain development, husbandry and related references and are linked to other relevant online resources.  The IMR will expand the existing collection of 871 accepted strains by approximately 60 strains each year.  Nearly 120,000 mice are distributed each year to researchers.  New strains recently accepted include models for Rett syndrome, juvenile Huntington’s disease, multiple endocrine neoplasia type 1 and hypercholesterolemia.  Candidate mutant strains that are considered for the IMR can be directly submitted by researchers through a form available on the IMR website.  The IMR website can be accessed at URL: http://www.jax.org/imr/index.html.


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