International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)

POSTER 13 - The CAST/Ei Strain Confers Significant Protection Against ApcMin - Intestinal Polyps, Independent of the Resistant Modifier of Min 1 (Mom1R) Locus

R. Koratkar
Kimmel Cancer Center, Jefferson Medical College

2) Pequignot E, 2) Hauck WW, and 1) Siracusa LD
1) Department of Microbiology and Immunology, Kimmel Cancer Center, 2) Biostatistics Section, Jefferson Medical College

Intestinal adenoma development in ApcMin mice is influenced by genetic background.  We generated a congenic line between the CAST and B6 inbred strains to study the effects of a resistant CAST background in the absence of a major modifier locus, Modifier of  Min 1 (Mom1R).  Progeny from a CAST.B6 Mom1R/S x B6 ApcMin/+ intercross were aged to 110 or 200 days, and screened for intestinal polyps. There was a significant decrease (p < 0.0001) in polyp multiplicity and size in CASTB6F1 Mom1R/S, ApcMin/+ and CASTB6F1 Mom1S/S, ApcMin/+ progeny compared to B6 Mom1S/S, ApcMin/+ controls.  A complete absence of colon polyps was observed in all mice heterozygous for the CAST background.  These results demonstrate that the CAST strain carries dominant modifier loci, in addition to Mom1R, that dramatically reduce polyp burden in the small intestine and eliminate polyp burden in the colon of ApcMin mice.

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