International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 16 - THE MOUSE GENOME DATABASE (MGD): A RICH RESOURCE FOR QUANTITATIVE TRAIT LOCI (QTLS)

I Lu
The Jackson Laboratory

Lutz CM, Bradt D, Blake JA, Bult CJ, Eppig JT and the Mouse Genome Informatics Staff.
The Jackson Laboratory

The Mouse Genome Database (MGD) is the premier mouse data resource serving the scientific community. MGD allows investigators to address complex queries for information from multiple sources in a fast and effective manner. Our goal at MGD is to facilitate the progress of scientific research by providing high-quality, easily accessible data. MGD is actively developing a robust representation of quantitative trait loci (QTLs). QTLs are regions of the genome with statistically significant linkage to a quantifiable trait, and are mapped using crosses of inbred strains differing in measurable traits such as blood pressure or life span. Each QTL region contains a gene or genes underlying the trait measured, which may then be identified via candidate gene analysis or positional cloning. QTL analysis is invaluable for dissection of complex diseases, often the culmination of multiple interacting genetic factors.QTLs are currently represented in MGD as a comprehensive summary of the mapping experiment, which includes information such as the LOD score, QTL range, linked markers, cross information, mode of inheritance, and potential candidate genes. As the text summary is not searchable, it is our goal to represent the information more prominently and allow complex QTL querying, such as by phenotype and/or strains. A recent development at MGD is the addition of allele and genotype annotations to QTLs. This aspect will be expanded to include full phenotype annotation, information on interactive loci, and more. Our ongoing efforts will allow MGD users to access a rich resource for QTLs with maximum effectiveness and benefit.


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Last modified: Saturday, November 3, 2012