International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 174 - GENOMIC ORGANIZATION AND EVOLUTIONARY RELATIONSHIPS IN THE CLUSTER OF GENES ENCODING MURINE 2’-5’-OLIGOADENYLATE SYNTHETASES

D Simon-Chazottes
Unité de Génétique des Mammifères, Institut Pasteur

1) Mashimo T, 2) Glaser P, 3) Lucas M, 1) Montagutelli X, 3) Desprès P, 1) Guénet JL
1) Unité de Génétique des Mammifères, 2) Laboratoire de Génomique des Microorganismes Pathogènes, 3) Unité des Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur

2’-5’-oligoadenylate synthetases (2’-5’-OASs) are interferon-inducible enzymes, which play an important role in the early innate defence mechanisms against viral infections. At the last Mouse Genome Conference, we reported that a non-sense mutation in the gene encoding OAS-L1 isoform was constantly associated with the susceptibility of several inbred strains of mouse to experimental infections with a pathogenic strain of the West Nile virus, suggesting that the inactivation of this isoform is the direct cause of the susceptibility (Mashimo et al. 2002 PNAS, in press).For the purpose of better understanding of the 2’-5’-OAS of cluster genes, we analysed its complete genomic structure. We found that mouse Oas2/Oas3 genes, which were not previously known, have a genomic organization very similar to human OAS2/OAS3. On the contrary, the mouse equivalent of human OAS1 exhibits a different organization with no less than eight (Oas1-1/Oas1-8) tandemly arranged genes. In addition to the genomic structure analysis, we established the evolutionary relationships among the family of these proteins. The phylogenic tree indicated that the mouse Oas1-X genes are probably a consequence of multiple duplications of the respective ancestor gene after the divergence of primates and rodents phyla. Finally, we discuss their possible functions in this communication.


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