International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 175 - GENOMIC STRUCTURES OF RECOMBINANT HEMOGLOBIN-BETA HAPLOTYPES IN ASIAN WILD MICE

K Moriwaki
RIKEN Tsukuba Institute Bioresource Center

2) Hirai K, 2) Kohigashi C, 2) Kawano S, 3) Miyashita N, 4) Kryukov AL, 4) Frisman LV, 5) Satta Y, 2) Yamaguchi Y
1) RIKEN BRC, 2) Fukuyama Univ, 3) Kagawa Med Coll, 4) Russian Acad Biol Soil Sci Inst, 5) Grad Univ Adv Stud

In wild mice of northeast Asia,we found a new haplotype Hbb-w1 (Kawashima et al,1995). Recombination of Hbb-b1-d and Hbb-b2-w1genes resulted in Hbb-p haplotype (Ueda et al,1999). In the natural populations, musculus subspecies group has  w1- and p-haplotype Hbb, while castaneus d-haplotype Hbb. An intra-Hbb complex recombination should have occurred in the hybrid between castaneus and musculus. It was estimated 0.1-0.5 MY ago by comparing the base substitution rate in b1 and b2 gene introns between d- and p-haplotype.  P-haplotype mice from several localities showed a common recombination in the region between b1 and b2 gene, suggesting a single event. Among the p-haplotype mice, no base substitution was observed in non-coding region near b1 gene.  Wild mice carrying p-haplotype must have spread recently. Broader distribution of Hbb-p in Asia and  human movement to east in history suggest that the recombination occurred at some place in central Asia.  Another haplotype Hbb-w2 was found in Kasakstan. The b1 gene was d-haplotype like, while b2 was neither d- nor w1- like. Nucleotide sequences of b1 and b2 genes demonstrated the possible recombination between w-1 and presumptive w-3 haplotype.


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