International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 178 - COMPARATIVE ANALYSIS OF THE Pdcd2-Tbp-Psmb1 REGION IN VERTEBRATES

Z Trachtulec
Institute Molec.Genetics

Vlcek C, Mihola O, Forejt J
Institute Molec. Genetics

Conserved synteny is defined as the presence of at least two pairs of orthologous genes, regardless of their order, on the same chromosome in two species, while the arrangement of the genes with the same order and orientation is called conserved linkage. Previously, we have found that a part of the conserved synteny between mouse chromosome 17 and human chromosome 6 can be extended to invertebrate genomes. Two most significant regions of synteny were identified, one of them encompassing genes orthologous to mouse chromosome 17 - human 6q27 region for Programmed cell death 2 (PDCD2), TATA-binding protein (TBP), and proteasomal subunit C5 (PSMB1). All three genes form a conserved linkage between the genomes of man and mouse. In C. elegans, the orthologs of these genes map into a region of 3.8 megabases (P = 0.0014). Here we determine the linkage status of these genes in non-mammalian vertebrates. We present an in silico analysis of the arrangement of these genes in fishes and the comparative analysis of a complete sequence of a chicken cosmid harboring the orthologs of at least two of these genes.This work is supported by grants No.: 204/01/0997 and 204/98/K015B from the Grant Agency of the Czech Republic.


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