International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)



13:15 13:45 HRS

Multi-Species Sequence Exploration: Targeted Studies of Vertebrate Genome Structure, Function, and Evolution

E Green
NIH Intramural Sequencing Center

Co-Authors: The NISC Comparative Sequencing Program
Institutions: NISC Comparative Sequencing Program

As a complement to ongoing efforts to sequence entire vertebrate genomes, we are sequencing the same targeted genomic regions in multiple species. To date, >200 Mb of sequence from >12 non-human species have been generated. These data provide myriad opportunities for comparative sequence analyses. For example, sequences from each of the species are being examined for architectural features of interest, in many cases revealing compositional and evolutionary characteristics for each vertebrate. In addition, the general patterns of sequence conservation are being assessed, revealing important insights about the general extents of conservation among different species and among different genomic regions. Finally, these data constitute a unique resource for delineating and measuring the complete spectrum of mutational events that shape the mammalian genome. In summary, our data are yielding valuable reconnaissance information for guiding decisions about which genomes to sequence in the future, are catalyzing the development of new computational tools and approaches for comparative sequence analysis, and are providing intriguing new insights about genome function and evolution.

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