International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)

Oral Presentation

Sunday 17 November

14:00 - 14:15 HRS


Y Hayashizaki
RIKEN Genomic Sciences Center

We have been working to establish the comprehensive mouse full-length cDNA collection and sequence database to cover as many genes as we can, named Riken mouse genome encyclopedia. More than 1,000,000 clones prepared from 163 tissues were end-sequenced to classify into 128,000 clusters and 60,000 representative clones were fully sequenced. As a conclusion, the 60,000 sequences contained 35,000 unique sequences with more than 24,000 clear protein-encoding genes. Using these results, functional analysis of specific proteins, such as motor protein, secreted protein, cytokine were carried out and gave new discovery to proteome research. Many new imprinted genes were found, and new candidates of transcription factors were listed up for further specific analysis as well.  Furthermore, mouse is the first higher organism that is analyzed both in full-length cDNA sequence and in Genome sequence, and it enabled us to compare these two set of data and do genome-wide substantial analysis. The next generation of life science is clearly based on all of the genome information and resources. Based on our cDNA clones we developed the additional system to explore gene function. We developed cDNA microarray system to print all of these cDNA clones, protein-protein interaction screening system, protein-DNA interaction screening system and so on. The integrated database of all the information is very useful not only for analysis of gene transcriptional network and for the connection of gene to phenotype to facilitate positional candidate approach. In this talk, the prospect of the application of these genome resourced should be discussed.

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