International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 26 - IN SILICO QTL MAPPING IN INBRED MOUSE STRAINS – CAN MICROSATELLITES HELP TO SPEED UP THE IDENTIFICATION OF NEW DISEASE TARGETS?

M Schuelke
AstraZeneca R&D Mölndal

A wide variety of pathophysiological phenotypes is common to mouse and Man. The mouse has therefore become the model organism of choice for trying to identify genes involved in these phenotypes. An in silico technique for QTL prediction based on multi-strain comparison of SNPs has been described.Here, the original approach was extended by including microsatellites into the analysis and modifications introducing a higher flexibility to the approach.Using published phenotypic data, several putative QTLs were identified for the following two asthma-related phenotypes: acetylcholine-induced airway hyperresponsiveness after ovalbumin (OVA)-sensitization and –challenge and OVA-specific serum IgE levels. Some of these QTLs corresponded to QTLs previously identified by conventional QTL mapping approaches.The method described here will benefit from both ongoing efforts to identify further polymorphisms in mouse by the MGSC and phenotyping programmes by the Mouse Phenome Database.


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