International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


POSTER 44 - BIOINFORMATICS IN MOUSE ENU MUTAGENESIS: A BRIDGE OF DATA GENERATION AND DATA COMMUNICATION IN THE MOUSE COMMUNITY

B Liu
Baylor College of Medicine

Zhong L, Tran N, Justice M
Baylor College of Medicine, Houston USA

The Mouse Mutagenesis for Developmental Defects project utilizes ENU as a powerful mutagen in mouse spermatogonial stem cells.  By determining the function of genes on a mouse chromosome, we can extrapolate to predict function on a human chromosome. To centralize the enormous amount of data generated in this project and present them to the mouse community, we are designing a web-based data handling system. It includes a virtual mouse facility management package with barcode system, a data recording system for various phenotypic screenings, a barcode system for frozen sperm, online mouse request databases and an email alert system of new mutants for registered mouse users.  To maximize benefit to the mouse community, we have recently been developing a system to bridge the public data view with the archived raw data.  Researchers can access the password protected website and instantly access the selected data available to public. Therefore, our data handling system can be accessed at different levels depending on the user privileges assigned.  To efficiently record the data from the mutants, the virtual mouse management with barcode system has been developed with substantial advances over other similar systems.  The interface and data organization in the system tries to imitate reality.  The changes of the data handling ‘culture’ are minimized such as you can virtually go to a mouse suite, a mouse room and a mouse rack, then open a cage to inventory the mice.  For more detailed information, visit our web site: http://www.mouse-genome.bcm.tmc.edu


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