International Mammalian Genome Society

The 16th International Mouse Genome Conference (2002)


M Bogue
The Jackson Laboratory

Marcus J, Grubb S
The Jackson Laboratory

Dissecting complex traits into genomic and environmental components will lead to a better understanding of normal and disease processes and will provide new targets for therapeutic intervention and alternative therapies for a wide range of applications, notably for the alarming drug resistance crisis.  Inbred strains of mice, used for decades to study normal human biology and disease, offer an excellent entry point to identify new models for understanding pathophysiology and genetic variation in response to a myriad of environmental factors.  Although inbred strains and their derivatives are an extraordinary resource for functional genomics, a lack of universally available phenotypic data for these strains leaves much of their potential for improving human health untapped.  To fill this resource gap and exploit the benefits of a completely sequenced mouse genome, the Mouse Phenome Project promotes the quantitative phenotypic characterization of a defined set of mouse strains under standardized conditions.  Phenotypic data are currently available for over 200 measurements, and efforts to collect SNPs data are underway as well.  Data are deposited in the MPD and are publicly available through a website interface (  International collaborative efforts are in progress to measure cardiovascular, neurological, behavioral, and other parameters.  As a community repository for quantitative phenotypic data, the MPD is an interdisciplinary tool for researchers using mouse models.  The MPD website provides a user-friendly interface to query the database and to analyze datasets.  MPD tools and applications will be demonstrated.

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Last modified: Saturday, November 3, 2012