International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 57 - INGENOTYPING –HIGH SPEED GENERATION OF ALLELIC VARIANTS FOR GENE FUNCTION ANALYSIS AND TARGET VALIDATION

Sedlmeier R
Ingenium Pharmaceuticals AG

Co-Authors: Peters T, Huffstadt U, Wattler S, Nehls M
Institutions: Ingenium Pharmaceuticals AG

The development of novel therapeutic concepts with high predictive value requires the functional analysis of target genes in vivo. The mouse is the model of choice for in vivo studies of gene function but the development of just one possible allelic variant is time consuming and costly. To fully exploit the power of genetics, a collection of animal models displaying each a different allele of the same gene would be ideal. In the past, generation of mouse models was dominated by gene targeting through homologous recombination, which requires sophisticated ES cell manipulation and chimera production. Here we report on INGENOtyping, an ENU-based approach allowing a much faster production of allelic variant animal models. INGENOtyping is null, hypomorphic and hypermorphic alleles.


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