International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 90 - PATHOLOGY OF CUSTOMIZED CELL TYPE SPECIFIC AUTOIMMUNITY IN HEMAGGLUTININ-TRANSGENIC MICE

Gruber AD
Department of Pathology, School of Veterinary Medicine Hannover, Germany

Co-Authors: Bruder D, Westendorf AM, Templin M, Buer J
Institutions: German Research Center for Biotechnology, Braunschweig, Germany

The regulatory mechanisms that control autoimmune phenomena are of considerable interest for a variety of disorders but available models are limited. Three lines of transgenic mice were generated with a partial influenza virus hemagglutinin (HA) coding sequence under expressional control of one of three cell type-specific gene promoters. Restricted HA expression was obtained by transcriptional control under the surfactant protein C (SPC) promoter (lung), the villin (VIL) promoter (intestine) or the insulin (INS) promoter (pancreas). No morphological or functional abnormalities were seen in these mice. However, when the mice were crossed with mice transgenic for an HA-specific T cell receptor (TCR-HA), the double transgenic mice developed severe autoimmune inflammation in the respective tissues. The SPC-HA x TCR-HA-, the VIL-HA x TCR-HA- and the INS-HA x TCR-HA- double transgenic mice will serve as models for cell-type specific immunological disorders including diabetes mellitus, inflammatory bowel disease and lupus erythematosus. Furthermore, the experimental approach should be useful for generating models for tissue-specific autoimmune inflammatory disorders in a variety of other cell types.


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