International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 91 - CHARACTERIZATION OF MOUSE MUTANTS WITH KINKY TAIL AND COILED TAIL FROM THE MUNICH ENU MUTAGENESIS SCREEN

Grundner-Culemann E
GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Muenchen-Neuherberg, Germany

Co-Authors: Abe K, Fuchs H, Hrabe de Angelis M
Institutions: GSF National Research Center for Environment and Health, Institute of Experimental Genetics, Muenchen-Neuherberg, Germany

Within the Munich ENU Mouse Mutagenesis Screen several mutants with defects in bone or cartilage development have been detected. In some of these mutants, we perform an in depth phenotypic characterization and high resolution genetic mapping.

Two dominant mutants show almost identical coiled tail skeletal phenotypes. The tails are short and coiled in heterozygous animals, and homozygous animals are embryonic lethal. Detailed skeletal analysis and genetic mapping are in progress.

The recessive mutant KTA041 shows a complex phenotype. Homozygous KTA041 mice are smaller than wild type mice. They have a shorter tail whereas the number of vertebrae is not changed. In most animals the tail is kinky, sometimes quite severe. Some rib vertebrae have abnormal shape. Strongly affected animals have rib fusions in the corresponding ribs. Mutants are kept on a pure C3HeB/FeJ background, mapping of recessive mutants is carried out via outcross-intercross breeding strategy with C57BL/6J. KTA041 was mapped to chromosome 17. High resolution gene mapping is in progress.


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