International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 103 - LOCI ON CHROMOSOMES 2, 4, 9 AND 16 FOR BODY WEIGHT, BODY LENGTH AND ADIPOSITY IDENTIFIED IN A GENOME SCAN OF AN F2 INTERCROSS BETWEEN THE 129P3/J AND C57BL/6BYJ MOUSE STRAINS

Li X
Monell Chemical Senses Center

Co-Authors: 1) Bachmanov A A, 1) McDaniel AH, 2) Lu K, 2) Li S, 1) Tordoff M G, 2) Price R A, 1) Reed D R
Institutions: 1) Monell Chemical Senses Center, 2) University Pennsylvania

Mice have proved to be a powerful model organism for understanding obesity in humans. Single gene mutants and genetically modified mice have been used to identify obesity genes, and the discovery of loci for polygenic forms of obesity in the mouse is an important next step. To pursue this goal, the inbred mouse strains 129P3/J (129) and C57BL/6ByJ (B6), which differ in body weight, body length and adiposity, were used in an F2 cross to identify loci affecting these phenotypes. Linkages were determined in a two-phase process. In the first phase, 169 randomly selected F2 mice were genotyped for 134 markers that covered all autosomes and the X chromosome. Significant linkages were found for body weight and body length on chromosome 2. In addition, we detected several suggestive linkages on chromosomes 2 (adiposity), 9 (body weight, body length, and adiposity) and 16 (adiposity), as well as two suggestive sex-dependent linkages for body length on chromosomes 4 and 9. In the second phase, 288 additional F2 mice were genotyped for markers near these regions of linkage. In the combined set of 457 F2 mice, six significant linkages were found on chromosome 2, 4, 8, 9 and 16. These results reinforce the concept that obesity is a complex trait. Genetic loci and their interactions, in conjunction with sex, age and diet, determine body size and adiposity in mice.


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