International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 115 - GENERATION AND ANALYSIS OF A MOUSE MUTANT DEFICIENT FOR THE ADHESION MOLECULE MADCAM-1

Schippers A
German Research Centre for Biotechnology, Braunschweig

Co-Authors: 2) Leuker C, 3) Gruber A, 2) Wagner N, 1) Mueller W
Institutions: 1) German Research Centre for Biotechnology, Braunschweig, 2) University of Cologne, 3) School of Veterinary Medicine, Hannover

Adhesion molecules are important mediators for lymphocyte migration to normal tissues and to inflammatory tissue sites. The mucosal addressin cell adhesion molecule-1 (MAdCAM-1) acts as an endothelial cell ligand for leukocyte homing receptor L-selectin and α4β7 integrin and is normally expressed in mucosa associated lymphoid tissue and spleen. It is thought to have a specific function in the correct formation of the marginal zone in spleen and lymphocyte homing in peyers patches and the intestinal lamina propria. Using a conditional mutagenesis strategy, we successfully targeted the MAdCAM-1 gene. In contrast to previous speculations the MAdCAM-deficient mouse line is viable and exhibits no obvious defects. A more detailed analysis however reveals certain architectural defects in the spleens and additional alterations in the composition of lymphoid tissues, in particular in the gut.


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