International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


ORAL PRESENTATION

MONDAY 10 NOVEMBER
14:15 – 14:30 HRS

ANXIETY SUSCEPTIBILITY QTL IN MOUSE MODEL : HOW FAR ARE WE FROM DISCOVERING A QT GENE?

Yalcin B
WTCHG, University of Oxford

Co-Authors: Fullerton J, Miller S, Mott R, Flint J
Institutions: WTCHG, University of Oxford

Using HS mice, we have fine mapped an anxiety susceptibility QTL on mouse chromosome 1 to an interval of 0.8 cM. We have established a 4.8-Mb high-resolution integrated BAC-based map underlying this region, encompassing 10 genes: 8 of which are known (B3Galt2, Glrx2, Ssa2, Uchl5) including 4 members of the RGS gene family and 2 unknown genes CDC73 homologue and retinoic acid inducible neural specific protein homologue. We sequenced all the genes in each of the 8 HS founders strains. We did not find any mutations that alter the genes. We have used a statistical approach to assign probabilities to all non coding polymorphisms identified as possible Quantitative Trait Nucleotides. Using a combination of different approaches such as haplotype structure and higher resolution mapping with the use of MF1 mice, it appears that two loci might be involved with different modes of action.


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