International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 142 - MOUSE GENOME INFORMATICS: NOMENCLATURE UPDATE

Maltais L J
The Jackson Laboratory

Co-Authors: Corey R J, Blake J A, Eppig JT
Institutions: The Jackson Laboratory

The Mouse Genomic Nomenclature Committee (MGNC) continues to deal with day-to-day nomenclature issues of assigning official nomenclature. Our objective is to provide standardized, unique designations for genes and genome features. We work from published and unpublished sources, through interactions with the HUGO Gene Nomenclature Committee (HGNC)) and in consultation with the research community. Quality control reports related to nomenclature are checked daily to monitor and update nomenclature entries in the Mouse Genome Informatics (MGI) resource (http://www.informatics.jax.org/). The MGI nomenclature group works closely with MGI sequence annotators and with the NCBI/LocusLink curation group to standardize representations of mouse genes with respect to their sequence representations.

Among recent updates to the nomenclature process, MGI will no longer display “–pending” symbols. Rather, it will be noted on the marker detail page that the symbol and name are interim and not approved. MGNC will continue to assign nomenclature to only full-length pseudogenes provided sequence accession IDs are associated with them.

In support of standardized nomenclature across the genomes, the International Society for Animal Genetics (ISAG), decided unanimously that “animal gene nomenclature should follow the rules for human gene nomenclature, including the use of identical symbols for homologous genes and the reservation of human symbols for yet unidentified animals genes". In support of this objective, the MGI Nomenclature group will continue to work closely with the HUGO [human] nomenclature group to provide a consistent representation of nomenclature for homologous genes in mammals.

Supported by NIH grant HG00330


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