International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 161 - MOUSE PHENOME PROJECT: BUILDING A COMMUNITY RESOURCE AND INTEGRAL TOOL FOR COMPLEX PHENOTYPE ANALYSIS

Bogue M
The Jackson Laboratory

Co-Authors: Marcus J, Grubb S
Institutions: The Jackson Laboratory

Comprehensive characterization of inbred strains is needed to identify new mouse models and to choose optimal strains for breeding strategies and other techniques, leading to the identification of genomic components contributing to complex phenotypes. The Mouse Phenome Project is an international and ongoing collaborative effort to promote the quantitative phenotypic characterization of a defined set of inbred mouse strains under standardized conditions and to make the data publicly available. With the guidance of an International Steering Committee and participation of the research community, we have coordinated efforts to choose an optimal set of 40 inbred strains, and we are interested in collecting data from these strains and their reproducible derivatives (F1 hybrids, RI lines, consomics, congenics). Collectively this reference population represents virtually unlimited but reproducible combinations of a set of fixed alleles from the original 40 strains. Members of the research community are contributing valuable datasets for inclusion in the Mouse Phenome Database (MPD; www.jax.org/phenome). There are about 500 measurements and 450K SNPs currently available with a number of new initiatives underway. We are coordinating with large-scale genotyping consortia (MIT and GNF-Novartis) with the goal of identifying 50,000 SNPs in 47 inbred strains. We are eager to establish additional collaborations with members of the research community and to and work with large-scale consortia to develop integrated datasets that enhance the value of the data and maximize community resources. We welcome community input to define MPD directives.


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