International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 172 - A QTL INFLUENCING CORPUS CALLOSUM SIZE IS LOCATED ON THE X CHROMOSOME

Kusek G
Genomics Institute, Wadsworth Center

Co-Authors: 1) Bolivar V, 3) Wahlsten D, 1,2) Flaherty L
Institutions: 1) Genomics Institute, Wadsworth Center, 2) Department of Biomedical Sciences, University at Albany, 3) Department of Psychology and Centre for Neuroscience, University of Alberta

The corpus callosum is the largest fiber tract in the brain that connects the left and right cerebral hemispheres. Corpus callosum size is a complex quantitative trait showing a continuous range of values and is likely influenced by interactions between multiple genes and environmental effects. Reciprocal crosses between BTBR T/+ tf/tf (BTBR) (lacking a corpus callosum) and BALB/cByJ (BALB) (having a corpus callosum) indicate the presence of a gene on the X chromosome affecting corpus callosum size. Midsagittal corpus callosum area was measured in male and female F1 offspring from reciprocal crosses between BTBR and BALB mice. Analysis of variance (ANOVA) showed significant differences in the midsagittal corpus callosum area between (BTBR x BALB)F1 and (BALB x BTBR)F1 male mice (p=.0006), while there was no difference in midsagittal corpus callosum area between reciprocal females (p=.7265). Specifically, the presence of the X chromosome derived from BTBR was associated with a decrease in the mean midsagittal area of the corpus callosum as would be expected given BTBR male and female mice completely lack the structure.


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