International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


ORAL PRESENTATION

TUESDAY 11 NOVEMBER
14:30 – 14:45 HRS

NOVEL COMPONENTS OF DELTA-NOTCH SIGNAL TRANSDUCTION

Pfister S
GSF – National Research Center for Environment and Health

Co-Authors: Przemeck G K, Gerber J K, Beckers J, Adamski J, Hrabe de Angelis M
Institutions: GSF – National Research Center for Environment and Health

The evolutionary conserved Notch-signal transduction pathway regulates cell fate and cellular differentiation in various tissues and has essential functions in embryonic patterning and tumorigenesis. Cell-cell signaling by the Notch pathway is mediated by the interaction of the transmembrane receptor Notch with its ligands Delta and Jagged presented on adjacent cells. Whereas signal transduction to Notch expressing cells has been described, it is yet unclear whether Delta-dependent signaling may also exist within the Delta expressing cell. Here, we report on the identification of proteins, interacting with the intracellular domain of Delta1 (Dll1). In situ expression analyses in mouse embryos reveal distinct expression patterns, partly overlapping with Dll1, for example, in the central nervous system and the vibrissae buds. In addition, we find that expression of at least one of the proteins is altered in Dll1 loss-of-function mouse embryos. Together, these observations suggest that Delta1 may trigger a yet unidentified intrinsic signal through its intracellular domain. This novel signal transduction role of Delta may have important implications for the understanding of Delta-Notch signaling and interpretation of Delta mutant phenotypes.


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