International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


ORAL PRESENTATION

TUESDAY 11 NOVEMBER
15:30 – 15:45 HRS

THE GERMAN MOUSE CLINIC – A PLATFORM FOR COMPREHENSIVE, STANDARDIZED PHENOTYPING OF MOUSE MUTANTS

Hrabe de Angelis M
Institute of Experimental Genetics, GSF - Research Center for Environment and Health, Neuherberg

Co-Authors: 1) Fuchs H, 1) Gailus-Durner V, 1) Lengger C, 2) Reinhard C, 2) Schulz H, 3) Calzada-Wack J, 4) Elvert R, 5) Dalke C, 6) Franz, 1) Grundner-Culemann E, 5) Hölter S, 7) Javaheri A, 6) Kalaydijev S, 8) Klempt M, 3) Kunder S, 1) Mijalski T, 5) Pedersen V, 1) Prehn C, 10) Radz I, 11) Schneider I, 4) Ehrhardt N, 1) Zybill C, 12) Bader M, 12) Birchmeier-Kohler C, 13) Brielmeier M, 12) Groβ V, 12) Hübner N, 14) Lengeling A, 12) Lewin G, 12) Morano I, 15) Müller W, 9) Reitmeir P, 13) Schmidt J, 12) Willnow T, 1) Adamski J, 1) Beckers J, 7) Behrendt H, 6) Busch D, 16) Favor J, 11) Gekeler F, 5) Graw J, 4) Heldmaier G, 2) Heyder J, 3) Höfler H, 4) Klingenspor M, 11) Klopstock T, 16) Meitinger T, 7) Ollert M, 3) Quintanilla-Martinez L, 8) Wolf E, 5) Wurst W, 10) Zimmer A
Institutions: 1) Institute of Experimental Genetics, GSF - Research Center for Environment and Health, Neuherberg. 2) Institute of Inhalation Biology, GSF - Research Center of Environment and Health, Neuherberg. 3) Institute of Pathology, GSF - Research Center of Environment and Health, Neuherberg. 4) Department of Biology, Animal Physiology, Philipps-Universität, Marburg. 5) Institute of Developmental Genetics, GSF - Research Center of Environment and Health, Neuherberg. 6) Institute of Medical Microbiology, Immunology and Hygiene, Technical University Munich. 7) Division of Enviromental Dermatology and Allergy, Technical University of Munich. 8) Lehrstuhl für Molekulare Tierzucht und Biotechnologie, Ludwig-Maximilians-University, Munich. 9) IGM, GSF - Research Center of Environment and Health, Neuherberg. 10) Universitätsklinikum Bonn. 11) Department of Neurology, Ludwig-Maximilians-University, Munich. 12) Max-Delbrück-Centrum für Molekulare Medizin, Berlin. 13) Department of Comparative Medicine, GSF - Research Center of Environment and Health, Neuherberg. 14) Research Group Infection Genetics, German Research Centre for Biotechnology. 15) Department of Experimental Immunology, German Research Centre for. 16) Institute of Human Genetics, GSF - Research Center of Environment and Health, Neuherberg

With the growing number of new interesting and valuable mouse mutants generated by various strategies (e.g. knock out, gene trapping or ENU-mutagenesis), the need for a comprehensive and standardized phenotype characterization of these mouse models rises. A comprehensive analysis via a set of parameters ranging over all fields of disease areas, will enable us to evaluate the potential power of these mouse models to be used to dissect biological pathways or for the validation of drug targets.

The German Mouse Clinic (GMC) offers a phenotyping platform for a comprehensive and standardized phenotyping of mouse mutants in the fields of behaviour, dysmorphology, bone and cartilage, neurology, eye function and development, clinical chemistry, immunology, allergy, steroid metabolism, nociception, expression profiling, lung function, energy metabolism and pathology. Additional screens for host-pathogen interaction, cardiovascular diseases and somatosensoric phenotyping are performed at collaborating institutes. In a primary screen 166 key parameters for the most important pathways are determined. In the case of promising results, more detailed analysis can be performed in secondary and tertiary screens.

By now, twelve mutant lines have started the primary screen which lasts 26 weeks. In two mutant lines, which have already finished the screening, we found a number of parameters with significant differences between mutants and controls, and thus assigned new, unexpected phenotypes to the mutant lines. More information can be found on our web-page www.mouseclinic.de

This work is supported by the National Genome Research Network NGFN (GR-010313).


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