International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


ORAL PRESENTATION

WEDNESDAY 12 NOVEMBER
12:15 – 12:30 HRS

PHYSIOLOGICAL BASIS OF RESISTANCE TO DIETARY OBESITY SEEN IN THE B6.LP MOUSE, CONGENIC FOR A REGION ON CHROMOSOME 2

Zuberi A R
Pennington Biomedical Research Center Louisiana State University

Co-Authors: MacGowan J, Richards B, Krishnan B
Institutions: Pennington Biomedical Research Center Louisiana State University

A novel B6.LP mice strain has been generated that contains a small 4-cM region derived from Chromosome 2 of the LP/J mouse introgressed onto the C57BL/6J strain. Male mice are resistant to dietary-induced obesity in response to a diet high in fat and sucrose (HFHS) relative to the obesity susceptible B6 mouse. Interestingly, these mice also differ in the circulating fasting insulin concentrations when fed either a low fat (chow) or HFHS diets, suggesting that a difference in insulin sensitivity may underlie the difference in obesity phenotype. We describe our efforts to discern the physiological basis for these phenotypes by determining the metabolic rate, thermogenesis, physical activity and food consumption on chow and HFHS-fed mice, and measurements of glucose tolerance and insulin sensitivity. Subcongenic mice containing recombinant chromosomes within the congenic region have been identified and their phenotyping has further refined the genetic region containing the gene(s) of interest. Some candidate genes fall within this region and are described. To determine if the resistance to adiposity phenotype is limited to only dietary induced obesity, we report the effect of the LP/J-derived congenic segment on the penetrance of adiposity and insulin resistance phenotypes of the homozygous and heterozygous mice carrying the monogenic recessive obesity mutation, leprob.


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