International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 8 - DDK SYNDROME OF EMBRYONIC LETHALITY: ANALYSIS OF THE CANDIDATE REGION

de la Casa-Esperon E
Temple University

Co-Authors: 1) Briscoe T, 2) Pardo-Manuel de Villena F, 1) Sapienza C
Institutions: 1) Temple University, 2) University of North Carolina

When females of the DDK inbred strain are mated to males of other inbred strains (C57BL/6, BALB/c), the vast majority of the resulting embryos die by the time of implantation. The reciprocal crosses (non-DDK females x DDK males) are fertile. This phenomenon, known as the DDK syndrome, is determined by a single locus (Om) in chromosome 11. We have defined and characterised a candidate region for Om. We have analysed the expression of genes located within the interval as well as studied the sequences of the candidate region, observing a number of repeats and deletions. We have also extended the study of these sequences to other inbred strains.


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