International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 33 - FUNCTIONAL ANALYSIS OF THE MAMMALIAN GENOME REVEALS NOVEL THERAPEUTIC ENTRY POINTS FOR HUMAN DISEASE

Grosse J
Ingenium Pharmaceuticals AG

Co-Authors: Stumm G, Laufs J, Augustin M, Sedlmayer R, Wattler S, Nehls M C
Institutions: Ingenium Pharmaceuticals AG

Key for the successful development of much-needed novel therapeutics is the discovery and fundamental understanding of disease processes and the identification of useful intervention points: a fact that became even more apparent with the increased failure rate of therapeutic compounds derived from poorly understood genomics-based targets.

In order to speed up the discovery of biomedically important processes, Ingenium developed two complementary genetics-based technologies: Deductive Genomics™ and INGENOtyping™.

Deductive Genomics™ allows querying essentially every mammalian gene in its organismal context for the potential function in fundamental disease processes.

As an example a mouse line with enhanced insulin sensitivity is presented. In contrast to insulin sensitizing compounds inducing obesity this animal model presents with decreased body fat content and is resistant to high fat diet induced insulin resistance. This provides a new perspective on insulin sensitization as a therapeutic strategy.

Following the Deductive Genomics™ – based discovery of novel pathways, each pathway member is analyzed for its specificity in an animal model before a promising drug discovery process can be outlined. INGENOtyping™ is currently one of the fastest methods for developing the required murine models. INGENOtyping™ is based on Ingenium's unique library of murine sperm, which on average represents several genetic variants of every mammalian gene. Sperm with alterations in the gene of interest can be easily selected and the corresponding murine model generated by in vitro fertilization.


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