International Mammalian Genome Society

17th International Mouse Genome Conference

9-12 November 2003, Braunschweig, Germany


POSTER 40 - PHYSICAL LINKAGE OF SIMILARLY REGULATED GENES AND CONTEXT-DEPENDENT REGULATION ON RIBOSOMAL PROTEIN GENES

Imai K
GSF-National Research Center for Environment and Health, Institute of Developmental Genetics

Co-Authors: Wahl M
Institutions: GSF-National Research Center for Environment and Health, Institute of Developmental Genetics

In recent years, a huge amount of information on global gene expression profiles in diverse tissue types has been accumulating. We have also carried out transcriptome analyses of chondrogenesis induced by BMP4 and of somitogenesis by using the method of SAGE (Serial Analysis of Gene Expression). Through analyses on our own data sets and also on those from others' studies, we realized two interesting possibilities: (1) a significant fraction of downstream target genes regulated by a given signaling pathway may physically link in certain chromosomal domains; (2) a characteristic pattern of up- or down-regulation of ribosomal protein genes may represent a status of cells or tissues in a certain biological context. The former point suggests the presence of a yet unknown but somehow general mechanism of gene regulation, while the latter point may lead to the identification of surrogate measures to assess the cellular status. We will present some examples of data that support these possibilities and will discuss their possible implications.


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