Plenary Presentations

VERNE CHAPMAN MEMORIAL LECTURE
THE MAMMALIAN GENETICS REVOLUTION: YESTERDAY, TODAY AND TOMORROW
Ken Paigen

NEW RESEARCH INITIATIVES AT THE JACKSON LABORATORY
Richard P Woychik and Scientific Staff, The Jackson Laboratory

FINE MAPPING QTL USING HETEROGENEOUS STOCKS
Richard Mott, Binnaz Yalcin, Jan Fullerton, Leah Solberg, William Valdar, Jonathan Flint

MOUSE MODELS FOR USHER SYNDROME
Karen Steel, R Libby, R Holme, T Self, W Marcotti, D Williams and C Kros

PLURIPOTENCY AND THE MAMMALIAN GERMLINE
Hans Schöler, Karin Hübner, Guy Fuhrmann, Lane K. Christenson, James Kehler, Rolland Reinbold, Rabindranath De La Fuente, Jennifer Wood, Jerome Strauss III and Michele Boiani

IMAGING FOR MOUSE PHENOTYPING
Mark Henkelman, XJ Chen, JG Sled, JF Cargill, G Hamarneh, N Kovacevic, L Baghdadi, FS Foster, Y-Q Zhou, J Bishop, N Bock, B Nieman, JR Walls, LM Davidson, J Dazai, N Lifshitz, C McKerlie, SL Adamson, J Rossant

MUTAGENESIS IN THE DISSECTION OF INNATE IMMUNE SENSING PATHWAYS
Bruce Beutler

GENETIC DISSECTION OF IMMUNITY TO INFECTION: THE HUMAN MODEL
Jean-Laurent Casanova, Laurent Abel

RATIONAL DESIGN OF MOUSE MODELS TO STUDY FOLATE-ASSOCIATED PATHOLOGIES
Patrick Stover

SYSTEMS BIOLOGY APPROACH TO UNDERSTAND CELLULAR FUNCTIONS
Hiroaki Kitano

Oral Presentations

IDENTIFICATION OF SEGMENTAL DUPLICATION WITHIN THE MOUSE GENOME
Church DM, Bailey J A, Agarwala R, Eichler E E

TOWARDS A SNP-BASED MOUSE HAPLOTYPE MAP
Pletcher M T, Batalov S, McClurg P, Barnes S W, Wiltshire T

FUNCTIONAL ANALYSIS OF THE MOUSE GENOME BY GENE TRAP MUTAGENESIS
Floss T, Seisenberger C, Ruiz P, van Sloun P, Schnütgen F, Füchtbauer EM, Franz Vauti, Arnold HH, Hansen J, von Melchner H, Wurst W.

FUNCTIONAL ANNOTATION OF MUTANT MOUSE ES CELL LINES BY EXPRESSION PROFILING
Symula D J, Curley B

TOWARD A WHOLE-GENOME MOUSE EXPRESSION MICROARRAY: USING THE NIA MOUSE GENE INDEX TO EXPAND THE NIA MOUSE DEVELOPMENT AND NIEHS TOXICOGENOMICS MICROARRAY PLATFORMS
Carter M G, Sharov A A, Dudekula D B, VanBuren V, Qian Y, Ko, M S H

GENE EXPRESSION PATTERNS OF THE MOUSE TRANSCRIPTOME
Wiltshire T, Walker J, Su A, Batalov S, Hogenesch J

IDENTIFICATION OF NOVEL DELTA/NOTCH TARGET GENES DURING MOUSE EMBRYONIC DEVELOPMENT USING DNA-CHIP AND PROTEIN EXPRESSION PROFILING
Machka C, Halder T, Harder A, Hrabe de Angelis M, Beckers J

HIPPOCAMPAL GENE EXPRESSION IN HETEROGENEOUS STOCK (HS) MICE SELECTED FOR LOW, MID AND HIGH PERFORMANCE ON COGNITIVE TASKS
Paya-Cano JL, Fernandes C, Liu L, Rijsdijk F, Plomin R, Schalkwyk LC

ANXIETY SUSCEPTIBILITY QTL IN MOUSE MODEL: HOW FAR ARE WE FROM DISCOVERING A QT GENE?
Yalcin B, Fullerton J, Miller S, Mott R, Flint J

A FUNCTIONAL SINGLE NUCLEOTIDE POLYMORPHISM IN CADHERIN 23 IS ASSOCIATED WITH POLYGENIC INHERITANCE AND GENETIC MODIFICATION OF SENSORINEURAL HEARING LOSS IN MICE
Noben-Trauth K, Zheng Q Y, Johnson K R

QUANTITATIVE TRAIT LOCI FOR HDL-CHOLESTEROL
Paigen B, Wang X, Lyons M, Korstanje R

A LOCUS ON CHROMOSOME 7 DETERMINES MARKED UPREGULATION OF OSTEOPONTIN IN MICE WITH DYSTROPHIC CARDIAC CALCIFICATION
Korff S, Aherrahrou Z, Kaczmarek P M, Axtner S B, Jurat A, Doehring L C, Weichenhan D, Katus H A, Ivandic B T

ODSM1 A LOCUS WITH MATERNAL EFFECT, SUPPRESS THE SEX REVERSAL IN THE ODSEX (ODS) MODEL
Poirier C, Qin Y, Truong C, Agoulnik A I, Bishop CE

REPRODUCTIVE ISOLATION AS A COMPLEX TRAIT: TOWARDS GENETIC ARCHITECTURE OF HYBRID STERILITY IN THE MOUSE
Forejt J, Trachtulec Z, Aixnerová R, Gregorova S, Krizan J, Divina P, Vlcek C, Paces V, Vacík T, Jansa P

DELETION OF THE ENDOGENOUS MOUSE SNCA GENE MARKEDLY EXACERBATES SYNUCLEINOPATHY IN TRANSGENIC MICE EXPRESSING Ala53>Thr HUMAN A-SYNUCLEIN
Cabin D E, Gispert-Sanchez S, Murphy D, Auburger G, Myers R, Nussbaum R

GENETIC CONTROL OF ADRENAL DEVELOPMENT AND FUNCTION: INTERACTION OF DAX1 AND STEROIDOGENIC FACTOR-1
Keegan C, Shah S, Jameson L, Hammer G

UTILISING THE P57KIP2 KNOCKOUT MOUSE TO UNDERSTAND CELL GROWTH PERTURBATION IN BECKWITH - WIEDEMANN SYNDROME
Lamprill E F, Digger K, Miller N, Barton S C, John R M, Surani A, Schofield P N

PHENOTYPIC ANALYSIS AND CHROMOSOMAL MAPPING OF MOUSE MUTANTS WITH CLINICALLY RELEVANT ALTERATIONS OF THE IMMUNE SYSTEM
Flaswinkel H, Rathkolb B, Reindl W, Howaldt M, Jakob T, Köllisch G, Sandholzer N, Soewarto D, Krebs O, Kremmer E, Hrabe de Angelis M, Balling R, Pfeffer K, Wolf E

DYSREGULATION OF T CELL RESPONSES IN MICE WITH T CELL-SPECIFIC INACTIVATION OF THE IL-10 GENE
Mueller W, Roers A, Siewe L, Strittmatter E, Deckert M, Schlüter D, Stenzel W, Gruber AD, Krieg T, Rajewsky K

FROM THE MIN MOUSE MODEL TO STUDIES OF THE INTESTINAL EPITHELIUM AND ITS NEOPLASMS IN THE MOUSE AND THE HUMAN
Dove W F, Chen X, Clipson L, Ehrhardt W, Haigis K, Halberg R, Hoff P, Kwong L, Newton M, Meyerand E, Pasch C, Shedlovsky A, Thliveris A, Weichert J, White A

NEW MOUSE MODELS OF TYPE II DIABETES FROM A SENSITISED N-ETHYL-N-NITROSOUREA (ENU) MUTAGENESIS SCREEN
Goldsworthy M, Mijat V, Haynes A E, Hugill A, Paul C L, Bentley E, Horner E J, Anstee Q M, Cox R D

UBIQUITINATION OF NOTCH PATHWAY DELTA LIGAND AND DEATH-ASSOCIATED PROTEIN KINASE IS ESSENTIAL TO MAINTAIN EMBRYONIC NEUROEPITHELIAL STEM CELLS
Barsi J C, Rajendra R, Wu J I, Artzt K

TARGETED DELETION OF FENS1 IN MICE LEADS TO INABILITY OF SPERM TO FERTILIZE
Bishop C, Rohozinski j, Ty M, Matzuk M, El Din N, Lamb D

A DEFECT IN A NOVEL ADAMTS FAMILY MEMBER IS THE CAUSE OF THE BELTED WHITE-SPOTTING MUTATION
Beier DR, Rao C, Foernzler D, Loftus S, Liu S, McPherson J, Jungers K, Apte S, Pavan W

NOVEL COMPONENTS OF DELTA-NOTCH SIGNAL TRANSDUCTION
Pfister S, Przemeck G K, Gerber J K, Beckers J, Adamski J, Hrabe de Angelis M

EUMORPHIA -- DEVELOPING NEW APPROACHES TO MOUSE PHENOTYPING
Brown SDM

THE GERMAN MOUSE CLINIC -- A PLATFORM FOR COMPREHENSIVE, STANDARDIZED PHENOTYPING OF MOUSE MUTANTS
Hrabe de Angelis M, Fuchs H, Gailus-Durner V, Lengger C, Reinhard C, Schulz H, Calzada-Wack J, Elvert R, Dalke C, Franz, Grundner-Culemann E, Hölter S, Javaheri A, Kalaydijev S, Klempt M, Kunder S, Mijalski T, Pedersen V, Prehn C, Radz I, Schneider I, Ehrhardt N, Zybill C, Bader M, Birchmeier-Kohler C, Brielmeier M, Groβ V, Hübner N, Lengeling A, Lewin G, Morano I, Müller W, Reitmeir P, Schmidt J, Willnow T, Adamski J, Beckers J, Behrendt H, Busch D, Favor J, Gekeler F, Graw J, Heldmaier G, Heyder J, Höfler H, Klingenspor M, Klopstock T, Meitinger T, Ollert M, Quintanilla-Martinez L, Wolf E, Wurst W, Zimmer A

HIGH-THROUGHPUT, NON-INVASIVE PROTOCOLS PROVIDE RELIABLE METHODS FOR EVALUATING HEART, LUNG AND SLEEP FUNCTION IN MICE
Svenson K L, Galante R, Pack A I, Walker J K, Schwartz D A, Barker J E, Peters L L

COMPARATIVE PATHOLOGY FOR FUNCTIONAL GENOMICS INITIATIVES
Brayton C

WOUND REPAIR AN IMPORTANT PATHWAY IN RESISTANCE TO L. MAJOR INFECTION
Foote S, Handman E, Ellso C, Speed T, Smyth G, Sakthianandeswaren A, Curtis J, Kumar B

THE IDENTIFICATION OF GENES CONTROLLING IMMUNE FUNCTION IN THE MOUSE BY GENOME-WIDE ENU MUTAGENESIS
Brunkow M E, Staehling-Hampton K, Appleby M, Gilchrist J, Britschgi T, Charmley P, Ebeling C, Howard T, Martin K, McEuen M, Paeper B, Proll S, Snell A, Tang P, Tittel P, Wasnick M, Wiegand N, Bouck J, Ramsdell F, Carlson G, Schatzman R

HOST-DEPENDENT VARIATION IN COLONIZATION BY THE GASTROINTESTINAL FLORA
Threadgill D W, Alexander A D, Hench G

ABNORMAL CONNECTIVE TISSUE REMODELING IN MICE DEFICIENT FOR RELAXIN RECEPTOR
Agoulnik A, Kamat A, Feng S, Bogatcheva N, Bishop C

PHYSIOLOGICAL BASIS OF RESISTANCE TO DIETARY OBESITY SEEN IN THE B6.LP MOUSE, CONGENIC FOR A REGION ON CHROMOSOME 2
Zuberi A R, MacGowan J, Richards B, Krishnan B

DEVELOPING PITUITARY TRANSCRIPTOME
Camper SA, Brinkmeier ML, Carninci P, Lyons RH, Shiraki T, Arakawa T, Kawai J, Hayashizaki Y

INTEGRATIVE TRANSOMIC ANALYSIS STRATEGIES REVEAL NOVEL INSIGHTS INTO POTENTIALLY IMPORTANT MOLECULAR PATHWAYS FOR MAMMARY TUMOR METASTASIS
Hunter K, Park Y-G, Yang H, Zhang J, Lukes L, Lancaster M, Buetow K

MAKING SENSE OF SEQUENCE: INTEGRATING BIOLOGICAL KNOWLEDGE WITH THE MOUSE GENOME
Bult CJ, Bradt D, Reed D, Zhu S, Qi D, Sinclair B, Blake J A, Ringwald M, Eppig JT, Richardson J E, Kadin J A, The Mouse Genome Informatics Group

AN INTEGRATED APPROACH TO MOUSE FUNCTIONAL GENOMIC DATA
Hedeler C, Else K J, Paton N W

Behavioural Genetics and Genomics

POSTER ABSTRACTS
POSTERS 1 - 7

1. INTERSTRAIN DIFFERENCES IN SOCIAL DOMINANCE AND HORMONAL TESTIS FUNCTION IN MICE
Busygina TV, Osadchuk A V

2. BEHAVIOURAL CHARACTERISATION OF WILD DERIVED MALE MICE (MUS MUSCULUS) OF THE PWD/Ph INBRED STRAIN
Fernandes C, Liu L, Paya-Cano JL, Gregorova S, Forejt J, Schalkwyk LC

3. IDENTIFICATION OF QTLS FOR HEAT AND CAPSAICIN SENSITIVITY BETWEEN MOUSE STRAINS KJR AND C57BL/6
Furuse T, Shiroishi T, Koide T

4. MAPPING AND CHARACTERISATION OF A NOVEL ENU MUTANT WITH A SHORT CIRCADIAN PERIOD AND REDUCED ENTRAINMENT TO LIGHT
Nolan P, Bacon Y, Breeds S, Clay J, Ooi A, Kerr S

5. IDENTIFICATION OF THE BASIC LEUCINE ZIPPER AND W2 DOMAINS 2, BZW2, AS A PUTATIVE CIRCADIAN QUANTATIVE TRAIT GENE
Pletcher M T, Hogenesch J, Kay S, Wiltshire T

6. GENE-DRIVEN MUTAGENESIS FOR MOUSE MUTANTS WITH NEUROLOGICAL GENES
Sezutsu H, Wada Y, Takahasi KR, Sakuraba Y, Kaneko S, Fujimoto N, Tsuchihashi K, Matsumoto R, Wakana S, Noda T, Shiroishi T, Gondo Y

7. ENHANCED LEARNING AND MEMORY IN MICE LACKING NA+/CA2+ EXCHANGER 2
ShinH-S, Jeon D, Yang Y, Jeong M, Rhim H, Philipson K

 

Development and Stem Cells

POSTER ABSTRACTS
POSTERS 8 - 22

8. DDK SYNDROME OF EMBRYONIC LETHALITY: ANALYSIS OF THE CANDIDATE REGION
de la Casa-Esperon E, Briscoe T, Pardo-Manuel de Villena F, Sapienza C

9. VELVET, A DOMINANT EGFR MUTATION THAT CAUSES WAVY HAIR AND DEFECTIVE EYELID DEVELOPMENT IN MICE
Du X, Hoebe K, Tabeta K, Liu H, Mann N, Mudd S, Crozat K, Sovath S, Gong X, Beutler B

10. KERATIN 14 CRE MICE PROVE MATERNAL OOCYTIC KERATIN 14 EXPRESSION
Hafner M, Haase I, Scharfetter-Kochaneck K, Pasparakis M, Schippers A, Krieg T, Müller W

11. ECTOPIC SOX10 EXPRESSION INDUCES ECTOPIC PIGMENT FORMATION IN NEURONAL CELL TYPES
Hakami R M, Arnheiter H, Pavan W J

12. CHARACTERIZATION OF EXPRESSION DIFFERENCES IN WAVED 3 MICE THAT LEAD TO ABNORMAL HEART AND SKIN DEVELOPMENT
Oliveri E, Parker A, Kinne J, Lien E, Olsen E, Beier D, Herron B

13. IDENTIFICATION OF THE BREAKPOINTS OF CHROMOSOMAL INVERSIONS IN HAIRY EAR (EH) AND KOALA (KOA) MUTANT MICE
Katayama K, Miyamoto S, Furuno A, Tsuji T, Kunieda T,

14. BCL11B, A TUMOR SUPPRESSOR GENE, IN T CELL DEVELOPMENT
Kominami R, Yu-ichi Wakabayashi

15. THE ROLES FOR RAD51D IN MAINTAINING GENOMIC STABILITY
Pittman D, Smiraldo P, Gruver A, Osborn J, Miller K, Albala J, Tarsounas M, Claas A, West S

16. DELTA/NOTCH SIGNALLING IS REQUIRED FOR PROPER NODE FORMATION
Vogel C, Przemeck GKH, Heinzmann U, Beckers J, Hrabe de Angelis M

17. MIND BOMB 1 – AN E3 LIGASE IN THE NOTCH-DELTA SIGNALING PATHWAY ESSENTIAL FOR EMBRYONIC DEVELOPMENT
Rajendra R, Barsi J C, Wu J I, Artzt K

18. CONTRIBUTION OF NEURAL CREST IN TRISOMIC AND EUPLOID MICE
Roper R J, South S T, Reeves R H

19. ROLE OF DE NOVO DNA METHYLTRANSFERASES IN GENOMIC IMPRINTING REVEALED BY CONDITIONAL GENE KNOCKOUT IN MICE
Sasaki H, Kaneda M, Sado T, Okano M, Hata K, Li E

20. MEMBERS OF A NOVEL GENE FAMILY Gsdm ARE EXPRESSED IN EPITHELIUM OF GASTROINTESTINAL TRACT AND SKIN
Tamura M, Fujii T, Tanaka S, Aoki A, Shiroishi T

21. POSITIONAL CLONING OF THE CAUSATIVE GENE FOR TWO MOUSE SKIN MUTATIONS, Rim3 AND Reden
Tanaka S, Aoki A, Sato H, Saeki N, Tamura M, Shiroishi T

22. IDENTIFY BZW2 AS A UNIQUE MOLECULAR MARKER FOR KIDNEY DESCENDING LIMB OF HENLE LOOP
Yu MY, Sha HB, Zeng H, Xie W, Gao X

Functional Genome Analysis

POSTER ABSTRACTS
POSTERS 23 - 72

23. CONTRIBUTION OF JAPANESE WILD MICE, MUS MUSCULUS MOLOSSINUS, TO GENOME CONSTITUTION OF C57BL/6 STRAIN
Abe K, Noguchi H, Tagawa K, Yuzuriha M, Toyoda A, Kojima T, Hattori M, Sakaki Y, Moriwaki K, Shiroishi T

24. VELOCIGENE: A HIGH-THROUGHPUT APPROACH FOR GENOME ENGINEERING, ASSIGNMENT OF GENE FUNCTION AND HIGH-RESOLUTION EXPRESSION ANALYSIS IN MICE
Adams N C, Economides A N, Murphy A J, Kraus P, Gale N W, Auerbach W, Frendewey D, DeChiara T M, Valenzuela D M, Yancopoulos G D

25. DOES OVEREXPRESSION OF THE IMPRINTED GENE NEURONATIN CAUSE A REDUCTION IN PITUITARY SIZE AND GROWTH HORMONE CELL NUMBERS?
Beechey C V, Peters J, Skinner J, Christian H, Fischer-Colbrie R

26. GENETIC MAPPING AND ANALYSIS OF HEAD SLANT (hslt), A NOVEL VESTIBULAR MUTANT WITH COMPLETE ABSENCE OF OTOCONIA
Bergstrom D, Gagnon L, Bergstrom R, Schimenti J, Johnson K

27. THE ULTIMATE™ ORF BROWSER: ADVANCED SEARCH TOOL AND INFORMATION CENTER FOR THE ULTIMATE™ ORF CLONE COLLECTION
Parvizi B, Yen J, Liang F, Boyaniwsky T

28. CAP ANALYSIS GENE EXPRESSION (CAGE) FOR HIGH THROUGHPUT ANALYSIS OF TRANSCRIPTIONAL STARING POINT AND IDENTIFICATION OF PROMOTER USAGE
1, Carninci P, 1, Shiraki T, Kondo S, Katayama S, 1, Waki K, Kasukawa T, Kawaji H, 1, Nakamura M, 1, Kodzius R, Arakawa T, Fukuda S, Sasaki D, Podhajska A, Kawai J, and 1, Hayashizaki Y

29. REGION SPECIFIC ENU MUTAGENESIS ON MOUSE CHROMOSOME 5
Ching Y, Wilson L, Howell G, Hartford S, Sears A, Schimenti J

30. FAST EVOLUTION OF THE MOUSE SEX CHROMOSOMES
Disteche C, Nguyen D K

31. A SENSITIZED ENU MUTAGENESIS SCREEN IN ANIMAL MODELS OF CHRONIC INFLAMMATORY DISEASES AS A TOOL FOR DRUG TARGET DISCOVERY
Douni E, Sekara E, Kamber M, Mantellou M, Kontoyiannis D, Kollias G

32. AN EXPRESSION GENE TRAP MUTAGENESIS RESOURCE AT THE CENTRE FOR MODELING HUMAN DISEASE (CMHD)
Epp T, Reid T, Hant P, Lan Q, Li C, Ohishi M, To C, Tsao N, Yu M, Kassam N, Osborne L, Rossant J, Stanford W

33. FUNCTIONAL ANALYSIS OF THE MAMMALIAN GENOME REVEALS NOVEL THERAPEUTIC ENTRY POINTS FOR HUMAN DISEASE
Grosse J, Stumm G, Laufs J, Augustin M, Sedlmayer R, Wattler S, Nehls M C

34. MAINTENANCE OF PARALOGS THROUGH SHUFFLING OF UPSTREAM REGULATORY SEQUENCES
Hafner M

35. NEUROPILIN-1: A SURFACE MARKER OF REGULATORY T CELLS
Hansen W, Bruder D, Probst-Kepper M, Westendorf A Geffers R von Boehmer H Buer J

36. IDENTIFICATION OF GENOMIC SITES OF TISSUE SPECIFIC DNA METHYLATION USING REAL AND VIRTUAL RESTRICTION LANDMARK GENOMIC SCANNING
Song F, Kimura MT Smith J Matsuyama T, Nagase H Held W A

37. CHEMICAL MUTAGENESIS OF MOUSE EMBRYONIC STEM CELLS
Greber B, Lehrach H, Himmelbauer H

38. COMMON AND DISTINCT EXPRESSION PATTERNS OF THE IGF-SYSTEM IN MICE IN RESPONSE TO DIVERGENT GROWTH SELECTION
Hoeflich A, Bünger L, Nedbal S, Renne U, Elmlinger M W, Blum W F, Bruley C, Kolb H J, Wolf E

39. IDENTIFICATION OF TUMOUR-ASSOCIATED GENES IN THE PROCESS OF MURINE SKIN CARCINOGENESIS
Hummerich L, Müller R, Wrobel G, Kokocinski F, Gack S, Schorpp-Kistner M, Fürstenberger G, Hess J, Hahn M, Angel P, Lichter P

40. PHYSICAL LINKAGE OF SIMILARLY REGULATED GENES AND CONTEXT-DEPENDENT REGULATION ON RIBOSOMAL PROTEIN GENES
Wahl M, Imai K

41. DEVELOPMENT OF THE FINE HISTOLOGICAL GENE EXPRESSION MAP FOR THE FUNCTIONAL GENOME ANALYSIS
Kusakabe M, Inoue J, Aotsuka S, Inoue T, Matsuba K

42. ANALYSIS OF ENU MUTAGENESIS-DERIVED MUTANTS WITH ABNORMAL LIMB DEVELOPMENT
Masuya H, Toki H, Shimizu A, Nagano J, Gondo Y, Wakana S, Noda T, Shiroishi T

43. MAPPING MUTATIONS ARISING FROM A LETHAL RECESSIVE SCREEN WITHIN THE Del(13)Svea36H REGION OF MOUSE CHROMOSOME 13
McKeone R, Southwell A, Cadman M, Arkell R, Davies J, Bogani D, Mallon A, Weekes J, Denny P, MRC Harwell

44. TOWARDS A COMPARATIVE PROTEOME/TRANSCRIPTOME ANALYSIS OF GENES EXPRESSED IN LIVER AND KIDNEY OF THE MOUSE
Mijalski T, Drobyshev A, Horsch M, Schädler S, Halder T, Harder A, Lottspeich L, Hrabe de Angelis M, JBeckers B

45. EMBRYONIC EXPRESSION OF Raidd USING β-gal REPORTER GENE IN TRANSGENIC MICE
Motaln H, McWhir J, Horvat S

46. ENHANCER FUNCTION IN THE MELANOCYTE LINEAGE
Murisier F, Guichard S, Beermann F

47. PHYSICAL MAP AND SEQUENCE ANALYSIS IN MOUSE T-COMPLEX
Nagaraja R, Brathwaite M, Waeltz P, Schroeder M, Jefferson J, Schein J, Marra M, Abe K and Roe B.

48. MOUSE BAC CGH ARRAY TO IDENTIFY GERM-LINE MUTATIONS INDUCED BY HEAVY ION BEAM (HIB) IRRADIATION
Kimura MT, Conroy JM, Nowak N, Igarashi J, Yoshiki A, Kusakabe M, Nagase H

49. BIODOSIMETRY BY DETECTING Γ-H2AX FOCI IN CB.17 MOUSE PERIPHERAL LYMPHOCYTES, ORGAN TISSUES AND SCID LYMPHOMA CELLS AFTER 137CS Γ-RAY IRRADIATION
Nakajima H, Tsuboi R, Nomura T

50. A DATABASE COMPARING DIFFERENTIAL EXPRESSION WITH HALLMARKS OF IMPRINTED GENES
Oakey R J, Underkoffler L A, Collins J N, Beechey C V, Choi J D

51. COMPARATIVE AND FUNCTIONAL CHARACTERIZATION OF THE PHR1 LOCUS
Peterson K, Burgess R, Johnson M, Roix J, Welsh I, O'Brien T

52. LARGE-SCALE IDENTIFICATION AND MAPPING OF NUCLEAR MATRIX-ATTACHMENT REGIONS IN THE DISTAL IMPRINTED DOMAIN OF MOUSE CHROMOSOME 7
Purbowasito W, Suda C, Yokomine T, Zubair M, Sado T, Tsutsui K, Sasaki H

53. NGFN XPRESS: GENOME-WIDE RNA EXPRESSION ANALYSIS OF MOUSE MODELS WITHIN THE NATIONAL GENOME RESEARCH NETWORK
Rieger S, Drobyshev A, Schulz H, Stöger T, Alessandrini F, Jakob T, Behrendt H, Seliger B, Graw J, Ziesenis A, Schmitt-John, Schachner M, Willnow T, Lengeling A, Hauser H, Klingenspor M, Chakraborty T, Hrabe de Angelis M, Beckers J

54. THE JUVENILE SPERMATOGONIAL DEPLETION (JSD) PHENOTYPE IS DUE TO A MUTATION WITHIN A NUCLEOLAR U3 RIBONUCLEOPROTEIN GENE REQUIRED FOR 18S RIBOSOMAL RNA BIOGENESIS
Rohozinski J, Bishop CE

55. FUNCTIONAL ANALYSIS OF THE MAMMALIAN GENOME BY LARGE SCALE GENE TRAP MUTAGENESIS
Ruiz P, Hansen J, Floss T, van Sloun P, Schnütgen F, Füchtbauer EM, Vauti F, Lehrach H, von Melchner H, and Wurst W

56. HIGH-THROUGHPUT MUTATION DISCOVERY BY MULTIPLEX TGCE (TEMPERATURE GRADIENT CAPILLARY ELECTROPHORESIS) IN MOUSE ENU-MUTAGENESIS
Sakuraba Y, Sezutsu H, Takahasi KR, Tsuchihashi K, Kaneko S, Fujimoto N, Matsumoto R, Ikeda A, Karashima Y, Inoue M, Kaneda H, Minowa O, Wakana S, Noda T, Shiroishi T, Gondo Y

57. INGENOTYPING -- HIGH SPEED GENERATION OF ALLELIC VARIANTS FOR GENE FUNCTION ANALYSIS AND TARGET VALIDATION
Sedlmeier R, Peters T, Huffstadt U, Wattler S, Nehls M

58. MOUSEEXPRESS: RNA EXPRESSION PROFILING OF ENU MOUSE MUTANTS
Seltmann M, Horsch M, Drobyshev A, Mader M, Tornow S, Frohme M, Korica T, Mewes W, Hoheisel J, Hrabe de Angelis M, Beckers J

59. DIRECTED MUTAGENESIS OF THE BROWN LOCUS ON CHROMOSOME 4 AND A HIGH THROUGHPUT SEQUENCE BASED SCREEN TO IDENTIFY MUTATIONS
Smyth I, Holdsworth A, Edgar R, White S, Taylor M, Gautier P, Justice M, Jackson I

60. The PDZ PROTEIN TIP-1 INHIBITS β-CATENIN TRANSCRIPTION ACTIVITY AND GROWTH OF COLORECTAL CANCER CELLS
Suzuki H, Kanamori M, Kai C, Hayashizaki Y, Sandy P, Marzinotto S, Benetti R, Schneider C

61. ESTABLISHMENT OF A SCREENING SYSTEM FOR MUTANTS AFFECTING GENOMIC IMPRINTING IN THE RIKEN-GSC PROJECT
Suzuki T, Furuumi H, Hashimoto M, Kaneda H, Gondo Y, Noda T, Wakana S, Ishino F, Sasaki H, Shiroishi T

62. DEVELOPMENTAL PROFILE OF DNA METHYLATION AND GENE EXPRESSION AT THE H19 LOCUS IN MICE LACKING SEQUENCE REQUIRED FOR GENOMIC IMPRINTING
Thorvaldsen J, Fedoriw A, Yang G, Nguyen S, Magnuson M, Bartolomei M

63. FINE AND DEEP HAPLOTYPE MAPPING OF CHROMOSOME 17 IN INBRED AND WILD MOUSE
Trachtulec Z, Vlcek C, Mihola O, Forejt J

64. NESPAS: THE UNRAVELLING STORY OF ITS FUNCTION IN THE GNAS IMPRINTING CLUSTER
Turner MD, Williamson C, Nottingham W, Ball S, Maconochie M, Peters J

65. MUTATION OF A NOVEL GENE IN THE MOUSE RESULTS IN REDUCTION OF BODY WEIGHT AND FAT TISSUE
Meyer N, Ruiz P, Suresh Kumar R, Arnold HH, Vauti F

66. SPROUTY4 (SPRY4) IS ESSENTIAL FOR CORRECT LIMB FORMATION
Suresh Kumar R, Vauti F, Arnold HH

67. THE MOUSE ORTHOLOG OF THE HUMAN FAC1 GENE: MOLECULAR AND FUNCTIONAL ANALYSIS OF A NOVEL GENE TRAP MOUSE LINE
Goller T, Suresh Kumar R, Ruiz P, Arnold HH, Vauti F

68. ANALYSIS OF A NEW MOUSE LINE WITH A GENE TRAP VECTOR INTEGRATION IN A KRAB ZINC-FINGER ENCODING GENE
Prochnow B R, Arnold HH, Vauti F

69. DEVELOPMENT OF ALTERNATIVE SPLICING LIBRARIES REVEALS THE COMPLEXITY OF ALTERNATIVE SPLICING IN MOUSE MELANOMA AND MELANOCYTE CELLS
Watahiki A, Shiraki T, Waki K, Kondo S, Ishizuka Y, Arakawa T, Kawai J, Hayashizaki Y, Carninci P

70. TRANSCRIPTIONAL ORGANISATION AND EXPRESSION ANALYSIS OF A NOVEL IMPRINTED GENE
Wood A J, Underkoffler L A, Collins J N, Choi J D, Beechey C V, Oakey R J.

71. DEVELOPMENTAL EXPRESSION PROFILE CHANGES OF THE ORGAN OF CORTI FROM DEAF MOUSE MUTANTS
Yang JW, Hardisty R, Varela A, Mburu P, Parkinson N, Willan J, Pritchard C, Underhill P, Hilton H, Madge J, Polley S, Carey AH, Jones H, Soares B, Brown S

72. STRUCTURAL AND FUNCTIONAL COMPARISONS BETWEEN THE IMPRINTED MASH2-IGF2-H19 REGION ON MOUSE CHROMOSOME 7 AND THE ORTHOLOGOUS REGION ON CHICKEN CHROMOSOME 5
Yokomine T, Sirohzu H, Purbowasito W, Toyoda A, Kato R, Suda C, Hori T, Tsudzuki M, Matsuda Y, Mizuno S, Hattori M, Mukai T, Sakaki Y, Sasaki H

Mouse Models of Human Disease

POSTER ABSTRACTS
POSTERS 73 - 134

73. A MOUSE MODEL OF INFLAMMATORY ARTHRITIS
Abe K, Wagner S, Kalaydijev S, Jakob T, Soewarto D, Fuchs H, Hrabe de Angelis M

74. A MODIFIER SCREEN FOR HUNTINGTON’S DISEASE
Acevedo-Arozena A, Chrobot N, Rubinsztein D C, Brown S D

75. ANALYSIS OF MCRII: A CONSERVED REGION OF THE WT1 ANTISENSE TRANSCRIPT
Allsop J, Moorwood K, Brown K, Malik K Ward A,

76. CHARACTERIZATION AND MAPPING OF THE YODA MUTATION
Barbaric I, Blake S, Hunter AJ, Brown SDM

77. FUNCTIONAL ANALYSIS OF THE DEVELOPMENT OF DIABETIC NEPHROPATHY IN MOUSE MODELS OF TYPE II DIABETES
Bentley E, Paul C L, Quarterman J M, Goldsworthy M, Cox R D

78. BARTMICE (BAYLOR, REPRODUCTIVE TRANSGENICS): A NATIONAL RESOURCE OF MICE, MUTANT IN GENES AFFECTING SEX DETERMINATION AND FERTILITY
Poirier C, Overbeek P, Bishop CE

79. MOUSE SPERM AND DNA ARCHIVING – BUILDING A PLATFORM FOR GENOME RESEARCH
Boersma A, Marschall S, Peters D, Hrabe de Angelis M

80. PATHOGENESIS OF CD4+ T CELL MEDIATED INFLAMMATION IN AN AUTOIMMUNE MOUSE MODEL OF PULMONARY DISEASE
Bruder D, Westendorf AM., Geffers R., Gruber AD., Buer J.

81. DEVELOPMENT OF SKIN AND HAIR-RELATED DEFECT MICE DERIVED ENU-MUTAGENESIS
Cho KH, Nam Y Y, Cho J W, Song C W, Han S S

82 A MUTATION IN ELOVL3 IS ASSOCIATED WITH HYPOLIPIDEMIA IN SCRAGGLY MICE
Collins K, DiRusso C, Herron B, Flaherty L

83. USING ENU TO DISCOVER GENES IMPORTANT FOR EYE DEVELOPMENT
Cross SH, Thaung C, Morgan J, West K, McKie L, Brunet J F, Brown SDM, Jackson I J

84. THE USE OF MICROARRAYS TO STUDY A MOUSE MODEL OF DISORDERS OF CHOLESTEROL BIOSYNTHESIS
Cunningham D, Swartzlander D, Caldas H, Armbruster D, Ray W, Herman G

85. FIRST APPROACH TO A NEW DOUBLE KO MOUSE: P21 AND P53 NULL. THE EPIGENETIC AS A KEY ANSWER FOR TUMORS
de la Cueva E, Herranz M, Fraga MF, Esteller M, Martín-Caballero J.

86. CONNECTING WITH PHENOTYPE: MAKING THE MOST OF WHAT WE KNOW
Eppig JT, Smith C, Goldsmith C W, Burkhart D L, Lu I, Taylor B A, Vanden Borre P, Washburn L L, Lennon-Pierce M, Lutz C

87. HAPLOINSUFFICIENCY OF CTCF LEADS TO TUMOR DEVELOPMENT IN MULTIPLE TISSUES IN MICE
Moore J M, Gurley K, Kemp C, Filippova G N

88. MUTATIONS IN DYNEIN LINK MOTOR NEURON DEGENERATION TO DEFECTS IN RETROGRADE TRANSPORT
Hafezparast M, Ahmad-Annuar A, Ruhrberg C, Lalli G, Shima D, Toda T, Schiavo G, Ball S, Peters J, Bowen S, Martin J E, Fisher E M C

89. FROM PHENOTYPE TO GENOTYPE: CHROMOSOMAL MAPPING AND SEQUENCING OF CANDIDATE GENES OF A HYPER IGE MOUSE MUTANT GENERATED BY GENOME WIDE MUTAGENESIS REVEALS A NOVEL MUTATION IN ZAP70
Flaswinkel H, Soewarto D, Köllisch G, Howaldt M, Hrabe de Angelis M, Balling R, Behrendt H, Ring J, Pfeffer K, Wolf E Jakob T

90. PATHOLOGY OF CUSTOMIZED CELL TYPE SPECIFIC AUTOIMMUNITY IN HEMAGGLUTININ-TRANSGENIC MICE
Gruber AD, Bruder D, Westendorf AM, Templin M, Buer J

91. CHARACTERIZATION OF MOUSE MUTANTS WITH KINKY TAIL AND COILED TAIL FROM THE MUNICHENU MUTAGENESIS SCREEN
Grundner-Culemann E, Abe K, Fuchs H, Hrabe de Angelis M

92. THE MOLECULAR DIFFERENCE BETWEEN RHABDOMYOSARCOMA CAUSED BY PATCHED- AND P53- MUTATIONS
Kappler R, Bauer R, Calzada-Wack J, Rosemann M, Hemmerlein B, Hahn H

93. JEFF, A SINGLE GENE MODEL OF OTITIS MEDIA
Hardisty R E, Morse S A, Logan K, Guionaud S, Sancho-Oliver S, Erven A, Steel KP, Brown SDM

94. TYPE 1 DIABETOGENIC GENES CENTROMERIC TO LMP2 IN NOD MICE
Hattori M, Fujisawa T, Noso S, Hattori K, 1, Lund T, Haskins K, Flavell R A, Wakeland E K

95. COMPLEMENT FACTOR 5 IS A GENETIC DETERMINANT OF LIVER FIBROGENESIS IN MICE AND HUMANS
Hillebrandt S, Matern S, Lammert F

96. CHARACTERISATION AND GENETICS OF A MOUSE MODEL OF HYPOPHOSPHATASIA
Hough T, Fisher E M C, Cheeseman M, Hunter AJ, Brown SDM

97. NOVEL MOUSE MODELS OF DIABETES MELLITUS -- IDENTIFICATION, MAPPING AND CHARACTERIZATION OF MUTANTS FROM THE RIKEN ENU MUTAGENESIS PROJECT
Inoue M, Sakuraba Y, Motegi H, Matsui J, Toki H, Shigeyama Y, Kubota N, Kaneda H, Ishijima J, Adachi T, Kagami T, Inoue A, Wakana S, Gondo Y, Minowa O, Shiroishi T, Noda T

98. IDENTIFICATION OF A MISSENSE MUTATION RESPONSIBLE FOR NEUROMUSCULAR DEGENERATION IN mnd2 MICE
Jones JM, Ji W, Saunders T L, Van Keuren M L, Meisler M H

99. INTERACTION OF SANS, THE HUMAN USHER 1G/MOUSE JACKSON SHAKER GENE PRODUCT, WITH OTHER USHER 1 GENE PRODUCTS
Kikkawa Y, Adato A, El-Amraoui A, Kominami R, Petit C, Yonekawa H

100. HUMAN DISEASE MODELS AT THE INDUCED MUTANT RESOURCE
Lane DB, Rockwood S F, Mobraaten L E, Davisson M T

101. MOUSE MODELS OF TELOMERE DYSFUNCTION
Lechel A, Ande S, Rudolph KL

102. DEVELOPMENT OF NEW MODELS FOR THE DOWN SYNDROME BY CHROMOSOMAL ENGINEERING IN THE MICE
Levavasseur F, Besson V, Brault V, Duchon A, Labbe M, Luo F, Magnol L, Herault Y,

103. LOCI ON CHROMOSOMES 2, 4, 9 AND 16 FOR BODY WEIGHT, BODY LENGTH AND ADIPOSITY IDENTIFIED IN A GENOME SCAN OF AN F2 INTERCROSS BETWEEN THE 129P3/J AND C57BL/6BYJ MOUSE STRAINS
Li X, Bachmanov A A, McDaniel AH, Lu K, Li S, Tordoff M G, Price R A, Reed D R

104. RETINAL COLOBOMA IN FLS MICE
Matsuura T, Kodama Y, Ozaki K, Hirasawa S, Narama I

105. IGF2: MULTIPLE MECHANISMS CO-ORDINATE BI-ALLELIC AND VARIEGATED EXPRESSION IN THE CHOROID PLEXUS
Menheniott T R, Charalambous M, Bennett W R, Kelly S M, Dell G, Ward A

106. AUTOMATED DNA PURIFICATION FROM MOUSE TAILS
Mulrooney C, Howe S, Oultram J, Robinson J, Maloney S, Sayle J

107. PANCREAS ANOMALY AND INTESTINAL TUMORS IN THE MOUSE SMALL EYE MUTANTS, PAX6SEY3H AND PAX6SEY4H
Nitta Y, Yoshida K, Nakagata N

108. TRUNCATION OF THE SHAKER-LIKE VOLTAGE-GATED POTASSIUM CHANNEL, KV1.1, CAUSES MEGENCEPHALY
Petersson S, Persson A-S, Johansen J, Ingvar M, Nilsson J, Klement G, Århem P, Schalling M, Lavebratt C

109. MOLECULAR CHARACTERIZATION OF THE POLYCYSTIC KIDNEY DISEASE CAUSING GENE BICC1
Price S J, Davis K L, Guay-Woodford L M, 1 & Bryda E C

110. MUTANT MICE SHOWING CLINICAL CHEMISTRY DEVIATIONS AS MODELS FOR HUMAN NEPHROPATHIES
Rathkolb B, Tran TV, Klempt M, Mohr M, Soewarto D, Hoffmann S, Hrabe de Angelis M, Wolf E Aigner B

111. NEW MUTANT MOUSE MODELS FOR INHERITED IRON METABOLISM DISORDERS
Rathkolb B, Klempt M, Mohr M, Soewarto D, Hoffmann S, Wagner S, Hrabe de Angelis M, Wolf E, Aigner B

112. GENETIC INSTABILITY IN A TRANSGENIC MOUSE MODEL FOR PHILADELPHIA CHROMOSOME-POSITIVE ALL
Rudolph C, Steinemann D, Hegazy AN, Schrock E, Klein C, Schlegelberger B

113. PHENOTYPIC CHARACTERIZATION AND MAPPING of LITTLE CHIN: an ENU-GENERATED MOUSE MUTANT THAT SHOWS CLEFT PALATE AND MICROGNATHIA
Saadi I, Herron B J, Bjork B C, Lund J J, Maas R L, Beier DR

114. THE Mus spretus VARIANT FOR Prkdc GENE, A FULLY DOMINANT ALLELE INVOLVED IN THE GENETIC DETERMINISM OF RESISTANCE TO GAMMA-RADIATION-INDUCED THYMIC LYMPHOMAS
Santos J, López P, Vaquero C, Matabuena M, Villa M, Fernández P, Montagutelli X, Szatanik M, Gué net JL and Fernández-Piqueras J.

115. GENERATION AND ANALYSIS OF A MOUSE MUTANT DEFICIENT FOR THE ADHESION MOLECULE MADCAM-1
Schippers A, Leuker C, Gruber A, Wagner N, Mueller W

116. IDENTIFICATION OF A NOVEL MOUSE MUSCULAR DYSTROPHY AND DEVELOPMENTAL LIMB DEFECT SYNDROME
Sher R B, Cox G A

117. DISRUPTION OF THE IMPRINTED GENE GRB10 IN MICE LEADS TO DISPROPORTIONATE OVERGROWTH WITH EFFECTS ON METABOLISM
Smith F M, Charalambous M, Bennett W R, Crew T E, Mackenzie F, Ward A.

118. SIXTY-FOUR MUTANTS FROM ENU MUTAGENESIS PROGRAM IN KIT/KRIC
Song C W, Cho KH, Cho J W, Lee P S, Kim Y E, Cha D S, Park H J, Kim C M, Kang M S, Nam Y Y, Yoon S J, Han S S

119. CHARACTERISATION AND GENETIC MAPPING OF THE PROGRESSIVE DEAFNESS MOUSE MUTANT OBLIVIOUS
Spiden S L, Fuchs H, Hrabe de Angelis M, Steel KP

120. UPDATE FROM JAX PGA: HIGH-THROUGHPUT PHENOTYPING OF MUTAGENIZED AND INBRED STRAINS PROVIDES ROBUST NEW MODELS OF HUMAN DISEASE
Svenson K L, Paigen B, O’Brien T P, Bult CJ, Macauley J B, Peters L L

121. CHARACTERIZATION OF alien, AN ENU-DERIVED MUTANT MOUSE WITH DEFECTS IN THE SONIC HEDGEHOG SIGNALING PATHWAY
Tran P, Herron B, Parker K, Qiu H, Beier DR

122. CHARACTERISATION OF ENU MUTANTS THAT ARE POTENTIAL MODELS FOR HUMAN CARDIOVASCULAR DISEASE
Van Agtmael T, McKie L, West K, Cross S, Jackson I J

123. A SYSTEMATIC, PHENOTYPE-DRIVEN MUTAGENESIS FOR GENE FUNCTION STUDIES: RECENT RESULTS OF THE MUNICH ENU-MOUSE-MUTAGENESIS SCREEN
Soewarto D, Wagner S, Rathkolb B, Fuchs H, Mohr M, Klempt M, Howaldt M, Kalaydijev S, Franz T, Schneider I, Marschall S, Boersma A, Schäble K, Tiedemann H, Schneltzer E, Steinkamp R, Alessandrini F, Jakob T, Binder E, Kremmer E, Behrendt H, Ring J, Zimmer A, Peters C, Flaswinkel H, Busch D, Pfeffer K, Klopstock T, Gekeler F, Ohl F, Balling R, Wolf E and Hrabe de Angelis M

124. ENU-INDUCED MUTANTS WITH HYPERACTIVITY: TOWARD A MOUSE MODEL OF ATTENTION DEFICITS AND HYPERACTIVITY DISORDER (ADHD)
Wada Y, Masuya H, Kaneda H, Ishijima J, Kobayashi K, Kawai A, Kushida T, Nishii R, Gondo Y, Noda T, Wakana S, Shiroishi T

125. RUBY EYE ACTS SEMIDOMINANTLY TO AFFECT HPS PATHWAYS
Webb L S, Gwynn B, Ciciotte S L, Smith R S, Peters L L

126. CD4+ T CELL MEDIATED CHRONIC INTESTINAL DISEASE: IMMUNE REGULATION VERSUS INFLAMMATION
Westendorf AM, Geffers R, Templin M, Buer J, Bruder D.

127. INADVERTANT INACTIVATION OF A NEARBY GENE IDENTIFIED BY ANALYSIS OF SEVERAL PLANH2 KNOCKOUT MOUSE LINES
Westrick R J, Mohlke K L, Korepta L M, Manning S L, Aiyagari A, Dougherty K M, Ginsburg D

128. A SENSITIZED ENU MUTAGENESIS SCREEN FOR DOMINANT GENETIC MODIFIERS OF THROMBOSIS IN THE FACTOR V LEIDEN MOUSE
Westrick R J, Manning S L, Aiyagari A, Siemieniak D R, Korepta L M, Ginsburg D

129. FUNCTIONAL CHARACTERISATION OF GENE TRAP MOUSE MUTANTS
Yalcin S, Floss T, Knobeloch K P, Eichele G, Melchner Hv, Wurst W, Lehrach H, Ruiz P

130. A SMALL DELETION HOTSPOT IN THE TYPE II KERATIN GENEmK6irs1/Krt2-6g ON MOUSE CHROMOSOME 15, A CANDIDATE FOR CAUSING THE WAVY HAIR OF THE Caracul (Ca) MUTATION
Kikkawa Y, Oyama A, Ishii R, Miura I, Amano T, Ishii Y, Yoshikawa Y, Masuya H, Wakana S, Shiroishi T, Taya C, Yonekawa H

131. GENETIC ANALYSIS OF THE HAIRPOOR MICE DERIVED FROM ENU-MUTAGENESIS
Kim J K, Kim E, Cha D S, amNam Y Y, Song C W, Yoon SK

132. SEX HORMONE RESPONSIBLE FOR GENERATION OF HEPATOCELLULAR CARCINOMA IN TRANSGENIC MICE EXPRESSING M-H-RAS
Wang A G, Moon H B, Lee D S, Yu DY

133. “MONTEZUMA” – A GENETIC IBD MOUSE MODEL CAUSED BY MUTATION OF A NOVEL GENE
Zeitlmann L, Schneider B, Grosse J

134. THE EUROPEAN MOUSE MUTANT ARCHIVE (EMMA)
Zeretzke S, Tocchini-Valentini G, Herault Y, Brown S, Ahrlund-Richter L, Mallo M, Cameron G, Hrabe de Angelis M

Mouse System Biology Bioinformatics

POSTER ABSTRACTS
POSTERS 135 - 155

135. ASSEMBLY AND ANNOTATION OF THE MOUSE GENOME- NCBI MOUSE RESOURCES
Church DM, Agarwala R, Chen H-C, Chetvernin S, Ermolaeva O, Geer R, Hlavina W, Jang W, Johnson P, Kans J, Katz K, Kitts P, Lipman D, Meric P, Ostell J, Pruitt K, Resenchuk S, Sapojnikov V, Schuler G, Sherry S, Shkeda A, Wagner L, Tatusova T, Maglott D

136. THE MOUSE GENOME INFORMATICS DATABASE: A COMPREHENSIVE ONLINE RESOURCE FOR THE MAMMALIAN GENOMICS RESEARCH COMMUNITY
Dene H, Blake J, Bult C, Ringwald M, Richardson J, Kadin J, Eppig J, and the MGI Staff.

137. GENE EXPRESSION PROFILING OF C56BL/6J MOUSE TESTIS BY SAGE
Divina P, Vlcek C, Paces V, Forejt J

138. KNOWLEDGE DISCOVERY FROM MOUSE MUTAGENESIS PROJECTS USING ONTOLOGIES
Gkoutos G Green E, Blake A, Simon M, Greenaway S, Mallon A-M, Hancock J M, Davidson D.

139. THE Del(13)Svea36H REGION OF CHROMOSOME 13: A GENE-DENSE REGION SUBJECT TO FREQUENT GENE DUPLICATION AND EVOLUTIONARY REARRANGEMENT
Mallon A-M, Wilming L, Weekes J, Ashurst J, Cadman M, Mc Keone R, Sellick C, Arkell R, Botcherby M R M, Strivens M A, Campbell R D, Gregory S, Hancock J M, Denny P, Rogers J, Brown SDM.

140. COMPUTATIONAL SOFTWARE FOR RESTRICTION LANDMARK GENOMIC SCANNING (RLGS) AND THE APPLICATION FOR MOUSE GENOME-WIDE METHYLATION SCREENING
Kimura MT, Song F, Okada H, Matsuyama T, Held W A, Nagase H

141. DATA MANAGEMENT IN THE GERMAN MOUSE CLINIC (GMC)
Lengger C, Gailus-Durner V, Steinkamp R, Schäble K F, Pargent W, Tiedemann H, Schneltzer E, Fuchs H, Hrabe de Angelis M

142. MOUSE GENOME INFORMATICS: NOMENCLATURE UPDATE
Maltais L J, Corey R J, Blake J A, Eppig JT

143. INTRODUCTION OF THE NATIONAL BIO RESOURCE PROJECT FOR THE RAT IN JAPAN
Mashimo T, Voigt B, Nakane Y, Yamasaki K, Nakanishi S, Kuramoto T, Serikawa T

144. INCYTE’S PROTEOME BIOKNOWLEDGE KNOWLEDGE LIBRARY™ A UNIQUE RESOURCE FOR COMPARATIVE GENOMIC AND PROTEOMIC ANALYSIS
O’Neill, K E, Hodge A, Hogan J, Peter-Davis A, Murphy L, Selfors L, Pagano S, Tillberg M

145. BIOINFORMATICS AND GENE DISCOVERY APPROACH TO PITUITARY DEVELOPMENT: Prop1 AND NOTCH SIGNALING
Raetzman L T, Brinkmeier M L, Ross S A, Carninci P, Shiraki T, Arakawa T, Kawai J, Lyons R H, Ward R D, Cook S, Dunwoodie S L, Camper S A, Thomas P Q, Hayashizaki Y

146. DOWN SYNDROME MOUSE MODELS Ts65Dn, Ts1Cje, AND Ms1Cje/Ts65Dn EXHIBIT VARIABLE SEVERITY OF CEREBELLAR PHENOTYPES
Reeves R H, Olson L E, Baxter L L, Carlson E J, Epstein CJ

147. PLANS FOR INTEGRATING MICROARRAY DATA IN MGI
Richardson J E, Blake J A, Bult CJ, Kadin J A, Eppig JT, Ringwald M, and the Mouse Genome Informatics Group

148. THE MOUSE GENE EXPRESSION DATABASE (GXD) AND THE GENE EXPRESSION NOTEBOOK (GEN)
Begley D A, McCright I J, Finger J H, Hayamizu T F, Hill D P, Smith C M, Beal J S, Corbani L E, Blake J A, Eppig JT, Kadin J A, Richardson J E, Ringwald M

149. PATHBASE; A DATABASE OF IMAGES OF SPONTANEOUS AND MUTANT MOUSE DISEASES
Schofield P N, Rozell B, Bard J B L, Sundberg J, Ward J, Hoefler H, Goessner W, Quintanilla-Fend L, Gruenberg M, Delvenne P, Boniver J, Orpin J, Covelli V, Mancuso M T, Ward A, Engstrom W, Sariola H, Ellender M, Hopewell J

150. 'ANONYMUS' - A LABORATORY INFORMATION MANAGEMENT SYSTEM FOR THE CAPTURE AND DISSEMINATION OF ANIMAL HUSBANDRY AND EXPERIMENTAL DATA
Selley R L, Jones PJR, Brundrett A C, Jones JD, Oxspring R J, Seymour M, Olver G H, Chandrasekar K, Johnson R

151. SAMPLE TRACKING SYSTEM (STS) FOR SAMPLE MANAGEMENT IN A LARGE SCALE MOUSE ENU MUTAGENESIS PROJECT
Steinkamp R, Schneltzer E, Tiedemann H, Soewarto D, Pargent W, Schäble K F, Lengger C, Wagner S, Hrabe de Angelis M

152. ACCELERATION OF POSITIONAL CLONING USING A HAPLOTYPE MAP OF THE INBRED LABORATORY MOUSE
Wade C M, Kulbokas E J, Kirby A, Karlsson E, Lander E S, Lindblad-Toh K, Daly M J

153. MOUSE GENOME ANALYSIS AND ANNOTATION AT THE SANGER INSTITUTE HAVANA GROUP
Wilming L

154. COLLECTION, PRESERVATION AND DISTRIBUTION OF MOUSE RESOURCE BY RIKEN BIORESOURCE CENTER --OVERVIEW OF ITS ACTIVITY AND FACILITIES
Yoshiki A, Nakata H, Ike F, Hiraiwa N, Yoshida-Noro C, Kazuyuki M, Keiji M, Yuichi Obata, Kazuo M

155. DUPLICATIONS, SYNTENY BLOCKS AND BREAKPOINTS FOR HUMAN, MOUSE AND RAT GENOMES: IMPLICATIONS IN GENOME EVOLUTION AND HUMAN DISEASE DEVELOPMENT
Zhao S, Shetty J., Shattsman S

Multigenic and Multifactorial Trait Analysis

POSTER ABSTRACTS
POSTERS 156 - 186

156. GENETIC STUDY ON X-LINKED HYBRID STERILITY IN THE B6-XPWD INTERSUBSPECIES CHROMOSOME SUBSTITUTION STRAIN
Aixnerová R, Gregorova S, Divina P, Buckiová D, Landíková M, Forejt J

157. SELECTION OF POSITIONAL CANDIDATE GENES FOR GROWTH AND OBESITY BY DIFFERENTIAL GENE EXPRESSION IN ADIPOSE TISSUE
Aksu S, Neuschl C, Renne U, Koczan D, Thiesen H J, Brockmann GA

158. GENETICS OF SKIN TUMOR PROMOTION SUSCEPTIBILITY
Angel J M, Riggs P K, Caballero M, DiGiovanni J

159. PHENOTYPIC AND GENETIC ANALYSIS OF THE INTESTINAL LENGTHENING IN PRM/ALF MICE
Aubin-Houzelstein G, Da Silva N R, Bellier S, Salaün P, Montagutelli X, Panthier J J

160. CHARACTERIZATION OF LOCI CAUSING AIRWAY HYPERRESPONSIVENESS USING PHENOTYPE-DRIVEN SELECTION AND CHROMOSOME SUBSTITUTION STRAINS
Ackerman K G, Grasemann H, Huang H, De Sanctis G T, Puma C, Singer J, Lander E, Hill A, Nadeau J, Drazen J M, Beier DR

161. MOUSE PHENOME PROJECT: BUILDING A COMMUNITY RESOURCE AND INTEGRAL TOOL FOR COMPLEX PHENOTYPE ANALYSIS
Bogue M, Marcus J, Grubb S.

162. ANALYSIS OF THE GENETIC VARIANCE OF BODY WEIGHT IN CHROMOSOME SUBSTITUTION STRAINS OF THE MOUSE LINE DU6I
Bevova M R, Aksu S, Aulchenko J, Renne U, Brockmann GA,

163. GENETIC DISSECTION OF DIET-INDUCED OBESITY RESISTANCE IN B6.A CHROMOSOME SUBSTITUTION STRAINS
Burrage L, Hill A, Singer J, Olszens K, Conti D, Witte J, Lander E, Nadeau J

164. GENETICS OF HOST RESISTANCE TO CHRONIC SALMONELLA INFECTION IN MICE
Caron J, Loredo-Osti J C, Morgan K, Malo D

165. INTERACTING QTL ON CHROMOSOMES 6 AND 15 UNDERLIE SALT-INDUCED HYPERTENSION BY REDUCING SODIUM EXCRETION
DiPetrillo K, Sheehan S, Whitmore H, Taylor E, and Paigen B

166. HAPLOTYPE MAPPING OF MEIOTIC DRIVE GENES USING WILD-DERIVED MOUSE STRAINS
Doherty H, Kim K, Bell T, Ideraabdullah F, Pardo-Manuel de Villena F

167. GENETIC AND ENVIRONMENTAL INTERACTIONS IN A MURINE OBESITY MODEL
Ehrich T, Kenney J, Hrbek T, Wang B, Pletscher L, Cheverud J

168. A SYNTHETIC MUTANT ON CHR 17 IS STERILE DUE TO LACK OF SPERM FLAGELLAE
Elliot R, Tabaczynski D, Pazik J, Hohman C.

169. DISSECTING COMPLEX MULTIGENIC TRAITS BY MAPPING GENES THAT ACT SYSTEMICALLY THROUGH THEIR INFLUENCE ON MACROPHAGE CHARACTERISTICS
Fijneman RJA, Vos M, Demant P, Kraal G

170. MOUSE GENETIC MODEL FOR ANTIGEN-INDUCED AIRWAY MANIFESTATIONS OF ASTHMA
Groot PC, Jeurink P V, Hofman G A, Nijkamp F P, Demant P, Van Oosterhouta A J M

171. QUANTITATIVE TRAIT LOCUS MAPPING OF GENES THAT REGULATE PHOSPHOLIPID TRANSFER ACTIVITY IN THE MOUSE
Korstanje R, Albers J, Wolfbauer G, Li R, Tu A-Y, Churchill G, Paigen B

172. A QTL INFLUENCING CORPUS CALLOSUM SIZE IS LOCATED ON THE X CHROMOSOME
Kusek G, Bolivar V, Wahlsten D, Flaherty L

173. MODELLING ANXIETY IN HETEROGENEOUS STOCK (HS) MICE: A NEW APPROACH FOR ASSESSING COMPLEX TRAIT IN AN OUTBRED MOUSE POPULATION
Liu L, Fernandes C, Rijsdijk F, Paya-Cano JL, Plomin R, Schalkwyk LC

174. WEBQTL: WEB-BASED COMPLEX TRAIT ANALYSIS
Manly KF. Wang J. Chesler E S. Williams R W.

175. TWO QUANTITATIVE TRAIT LOCI AFFECTING PROGRESSIVE HEARING LOSS IN 101/H MICE
Mashimo T, Erven A, Steel KP, Guénet J L

176. COMBINATION OF DATA FROM QTL MAPPING AND GENE EXPRESSION ANALYSES FOR THE SELECTION OF POSITIONAL CANDIDATE GENES FOR GROWTH AND OBESITY
Neuschl C, Aksu S, Renne U, Koczan D, Thiesen H J, Brockmann GA

177. GENETIC INCOMPATIBILITY BETWEEN X-LINKED LOCI AND TWO AUTOSOMAL REGIONS CAUSES HYBRID BREAKDOWN BETWEEN TWO MOUSE SUBSPECIES
Oka A, Mita A, Sakurai N, Yamamoto H, Takagi N, Takano-Shimizu T, Toshimori K, Moriwaki K, Shiroishi T

178. 3-LOCUS SEGREGATION MODEL OF THE LEYDIG CELL RESPONSIVENESS DURING THE POSTNATAL DEVELOPMENT IN MICE: MULTIGENIC AND MULTIVARIABLE APPROACH
Osadchuk A V

179. A GENOME-WIDE APPROACH FOR IDENTIFICATION OF MODIFIER GENES OF HIRSCHSPRUNG DISEASE IN THE SOX10DOM MOUSE MODEL
Owens S, Chandler R, Southard-Smith M

180. MAPPING AND SEQUENCING OF QTL FOR CARDIOVASCULAR PHENOTYPES ON RAT CHROMOSOMES 1 AND 10
Platzer M, Monti J, Tänzer S, Scharfe M, Gösele C, Glöckner G, Galgoczy P, Liska F, Blöcker H, Hübner N

181. MICROARRAY GENE EXPRESSION PROFILING IN CONGENIC STRAINS TO IDENTIFY CANDIDATE GENES FOR A QUANTITATIVE BEHAVIORAL TRAIT
Rodriguez de Ledesma A M, Bolivar V J, Isabelle J, Symula D, Flaherty L.

182. FINE MAPPING OF QTL’S UNDERLYING IMMUNITY TO SALMONELLA TYPHIMURIUM IN WILD-STRAIN MICE
Sancho V, Lacroix G, Malo D

183. ANALYSIS OF MODIFIER LOCI FOR THE NEUROLOGICAL- AND THE SPERMIOGENESIS PHENOTYPE OF THE WOBBLER MOUSE
Schmitt-John T, Mussmann A, Heimann P, Jockusch H, Ulbrich M

184. FURTHER RESEARCH OF THE RESISTANCE OF SPRET/EI TO TNF INDUCED LETHAL SHOCK
Staelens J, Vandenabeele A, Wielockx B, Puimège L, Hochepied T, Van Molle W, Affenas A, Van Roy F, Libert C.

185. MODIFIERS OF THE BRONXWALTZER MUTATION IN THE MOUSE
Nogueira C, Taylor A, Steel KP

186. AN ENU MUTAGENESIS SCREEN FOR EPIGENETIC MUTATIONS IN THE MOUSE
Thorvaldsen J, Percec I, Krapp C, Singer E, Nadeau J, Willard H, Bartolomei M

Nutrition and Metabolic Disease

POSTER ABSTRACTS
POSTERS 187 - 191

187. CHARACTERIZATION OF NSDHL PROTEIN SUBCELLULAR LOCALIZATION
Caldas H, Herman G

188. TARGETED DISRUPTION OF THE PEPTIDE TRANSPORTER PEPT2 IN MICE LEADS TO ALTERED RENAL HANDLING OF PEPTIDES
Frey I, Rubio-Aliaga I, Eichinger H M, Daniel H

189. INHIBITION OF DIABETIC NEPHROPHATHY BY AMINOGUANIDINE IN DB/DB MICE
Lu Y, Gao X

190. ANALYSIS OF DIFFERENTIALLY EXPRESSED TRANSCRIPTS FOUND BETWEEN CONGENIC LINES DIFFERING IN AN OBESITY QTL REGION
Stylianou I M, Keightley P D, Bünger L, Clinton M, Bulfield G, Pritchard C, Underhill P, Horvat S

191. MICE WITH HAPLOINSUFFICIENCY FOR THE LIPID PHOSPHATASE PTEN EXHIBIT INSULIN HYPERSENSITIVITY
Wong J T, Parsons R, Verchere C B, Ong C J

Phenotyping Methods Imaging

POSTER ABSTRACTS
POSTERS 192 - 200

192. IN VIVO BRAIN PHENOTYPING WITH MRI IN CDF/CDF MICE
Bock NA, Davidson L M, Kovacevic N, Lipina T V, Roder J C, Henkelman R M

193. EUMORPHIA AND THE SENSORY SYSTEMS
Coghill EL, Brown SDM, Thaung C, Meziane H, Romand R, Picaud S, Hart A, Cross S, Jackson I.

194. EIGHT FLUORESCENCE ANALYSIS ON A FOUR FLUORESCENCE FLOW ANALYSER
Deiters U, Mueller W

195. MRI FOLLOW-UP OF THE ANTI-TUMORAL EFFECT OF HYSTONE DEACETYLASE INHIBITORS (HDACIS) IN A GAMMA-IRRADIATED MOUSE LYMPHOMA MODEL
Herranz M, de la Cueva E, Villar-Garea A, Fraga MF, Martín-Caballero J, Esteller, M

196. GENETIC DISSECTION OF MICE BEHAVIOURAL PHENOTYPES IN AN ENRICHED HOME CAGE
Kas M, Spruijt B, Olivier B, van Ree J, Adan RAH, van Lith H, van Oost BA, Burbach J

197. THE CLINICAL-CHEMICAL SCREEN IN THE GERMAN MOUSE CLINIC
Klempt M, Holupirek E, Rathkolb B, Gailus-Durner V, Fuchs H, Hrabe de Angelis M Wolf E

198. A NEW METHOD FOR CONDITIONAL IMMORTALIZATION OF CELLS FROM MOUSE MUTANTS
May T, Hauser H, Wirth D

199. THE TENNESSEE MOUSE GENOME CONSORTIUM (TMGC) NEUROMUTAGENESIS PROGRAM: SCREENING FOR ABNORMALITIES OF THE NERVOUS SYSTEM AND BEHAVIOR
Miller D, Rinchik, E.M, Goss K, Johnson D, Snoddy J, Galloway L, Ferkin M, Hamre K, Matthews D, Mittleman G, Jablonski M, Williams R, Swanson D, Goldowitz D and the Tennessee Mouse Genome Consortium.

200. SCREENING FOR NEUROLOGICAL MUTATIONS AT THE JAX-NEUROSCIENCE MUTAGENESIS FACILITY (NMF)
Pretel S, Frankel WN, Seburn KL and the JAX-NMF Staff

The Genetics and Genomics of Infectious Disease

POSTER ABSTRACTS
POSTERS 201 - 216

201. GENETIC ANALYSIS OF HOST SUSEPTIBILITY TO CARDIOVIRULENT COXSACKIE VIRUS B3 INFECTION
Aly M, Vidal S

202. THE GENETICS OF SUSCEPTIBILITY TO SYSTEMIC PNEUMOCOCCAL INFECTION
Boubbane L, Haynes A, Moyes S, Hopes E, Gingles N Broman K, McPheat W, Morten J, Alexander J, Andrew P, Brown S, Denny P

203. GENETIC MODULATORS OF NATURAL RESISTANCE TO MOUSE CYTOMEGALOVIRUS INFECTION
Desrosiers M P, Vidal S

204. HOST DEFENCE AGAINST CYTOMEGALOVIRUS INFECTION IN WILD-DERIVED MOUSE STRAINS: IS THERE ALLELIC OR GENETIC HETEROGENEITY WITHIN THE Ly49 GENE FAMILY?
Girard A S, Guénet J L, Colucci F, Vidal S

205. IMPACT OF THE MAJOR HISTOCOMPATIBILITY COMPLEX HAPLOTYPE IN RESISTANCE OF CONGENIC BALB MICE TO GROUP A STREPTOCOCCAL INFECTION
Goldmann O, Müller A, Lengeling A, Chhatwal G S, Medina E

206. THE VITAMIN D RECEPTOR GENE AS AN INFECTION SUSCEPTIBILITY GENE: ANALYSIS OF IMMUNE MECHANISMS IN VDR-KO MICE
Helming L, Ehrchen J, Buer J, Probst-Kepper M, Gunzer M, Erben R, Balling R, Lengeling A

207. POSITIONAL CLONING OF LPS2, A KEY TRANSDUCER OF MYD88-INDEPENDENT TIR SIGNALING
Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim S O, Goode J, Mann N, Mudd S, Crozat K, Sovath S, Han J, Beutler B

208. HIGH RESOLUTION MAPPING OF QTL CONTROLLING RESISTANCE TO GASTROINTESTINAL WORMS IN MICE USING ADVANCED INTERCROSS LINES
Iraqi F A, Mugambi J, Nagda S, Gibson J P, Wakelin D, Baker R L, Behnke J

209. GENETIC DISSECTION OF COMPLEX DISEASE: LEISHMANIA MAJOR INFECTION MODEL
Lipoldová M Svobodová M, Havelková H, Badalová J, Vladimirov V, Vojtíšková J, Blažková H, Krulová M, Pilčík T, Krulová M, Volf P, Demant P

210. SUSCEPTIBILITY TO TUBERCULOSIS: A LOCUS ON MOUSE CHROMOSOME 19 (TRL-4) REGULATES M. TUBERCULOSIS REPLICATION IN THE LUNGS
Mitsos L M, Nantel A, Cardon L R, Ryan L, LaCourse R, North R J, Gros P.

211. ESTABLISHMENT OF A MOUSE INFECTION CHALLENGE PLATFORM
Pasche B, Franz T, Kalaydijev S, Helming L, Schiebe S, Deiters U, Gailus-Durner V, Hrabe de Angelis M, Müller W, Busch D H, Lengeling A

212. INNATE IMMUNE RESPONSES IN THE WILD-DERIVED MICE
Poltorak A, Smirnova I, Hoebe K

213. ISOLATION OF GENES IMPLICATED IN IMMUNE RESPONSES AGAINST INTRACELLULAR PATHOGENS USING ENU MUTAGENESIS SCREENING IN THE MOUSE
Rutschmann S, Du X, Beutler B

214. GENE EXPRESSION PROFILING DURING THE EARLY HOST RESPONSE TO SALMONELLA INFECTION IN MICE
Salez L, Bihl F, Malo D.

215. CpG1, A NOVEL DOMINANT MUTATION IN THE Tlr9 LOCUS, CONFERS UNRESPONSIVENESS TO UNMETHYLATED DINUCLEOTIDE
Tabeta K, Du X, Hoebe K, Goode J, Mudd S, Sovath S, Beutler B

216. HAPLOTYPE-SPECIFIC CLASS I GENE CONTENT OF THE H2-D/Q REGION OF THE MOUSE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC)
Takada T, Kumánovics A, Yonekawa H, Fischer Lindahl K