International Mammalian Genome Society

logo18th International Mouse Genome Conference

17-22 October 2004, Seattle, USA


PLENARY PRESENTATION

THURSDAY OCTOBER 21

8.30am – 9.00am

Genetics of host resistance to cytomegalovirus infection: Role of h2 and nk receptors

Vidal S

McGill University, Montreal, Canada

Human cytomegalovirus (CMV) infection can cause life-threatening disease in immunodeficient hosts. Experimental infection in mice has revealed that natural resistance to mouse CMV is genetically determined and mediated by binding of the natural killer (NK) cell activating receptor Ly49H to the pathogen-encoded glycoprotein m157. Novel data indicate multiple NK cell receptor gene mechanisms, including genetic and functional interactions with MHC receptor genes, that are crucial to the recognition of the infected cells and the eradication of the infection.

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