International Mammalian Genome Society

logo18th International Mouse Genome Conference

17-22 October 2004, Seattle, USA


POSTER 112 -  MOUSE PHENOME PROJECT

Bogue MA, Grubb SC

The Jackson Laboratory, Bar Harbor, Maine, United States

The Mouse Phenome Project is an ongoing international collaborative effort to enhance the research potential of the laboratory mouse by a) promoting the phenotypic and genotypic characterization of a set of 40 inbred strains and their derivatives, and b) making the data publicly available through a web-accessible database, the Mouse Phenome Database (MPD; www.jax.org/phenome) [Grubb et al., 2004].  We have collected and annotated over 600 measurements that include a broad range of metabolic, developmental, and behavioral parameters relevant to human disease.  Also, large volumes of SNP data are being incorporated into the MPD to maximize community SNP resources.  More than 450,000 SNPs have been identified by large-scale genotyping consortia in a subset of the Project's 40 priority strains and contributed to the MPD.  Strain characteristics and genotypic data have proven to be a valuable resource for the biomedical research community, as indicated by the increasing use of the MPD and significant advances using the data and associated analytical tools to uncover information on the genetic and biological factors involved in normal and disease pathways.  Expansion of the Mouse Phenome Project will allow the biomedical research community to continue to exploit quantitative phenotypic data together with emerging sequence, SNP, and haplotype data.  Project status and analysis tools will be highlighted.

Grubb SC, Churchill GA, Bogue MA. A collaborative database of inbred mouse strain characteristics. Bioinformatics. 2004 May 6 [Epub ahead of print] PMID: 15130929.

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