International Mammalian Genome Society

logo18th International Mouse Genome Conference

17-22 October 2004, Seattle, USA


POSTER 182 - MODELS OF HUMAN CANCER AT THE CLICK OF A MOUSE: THE MOUSE TUMOR BIOLOGY (MTB) DATABASE

Bult CJ, Krupke DM, Allio T, Vincent M, Sundberg JP, Mikaelian I, Eppig JT

The Jackson Laboratory, Bar Harbor, United States

The Mouse Tumor Biology Database (http://www.tumor.informatics.jax.org) is a freely accessible on-line informatics resource designed to support the use of the mouse as a model system of hereditary and induced cancers. The database was designed around the principle that genetic background is a key factor influencing the kinds and onset of cancers observed in different strains of genetically defined mice. MTB provides cancer genetics researchers with access to data regarding various mouse models for cancer including such information as tumor names and classifications, tumor incidence and latency data in different strains of mice, tumor pathology reports and images, information on genetic factors associated with tumors and tumor development, and literature references.

MTB provides users with a powerful web-base query interface that supports complex ad hoc queries. For example, users can query the database with questions such as "Which transgenic strains of mice have a high incidence of lung adenocarcinomas?" or "Show me tumor records where a point mutation was detected in Kras2" or "What spontaneous tumors are found in the inbred strain A/J?". The key to enabling these sorts of queries in MTB is the integration of mouse tumor data from many sources, primarily the published literature, and the use of standardized nomenclature and controlled vocabularies.Terms for classifying tumors, organ and tissue names, strain type, reproductive status, and mutation type have been standardized in MTB annotations. This allows consistent searching within MTB and provides the ability to compare and link MTB records with those in other resources such as the Mouse Models of Human Cancer Consoritum (http://emice.nci.nih.gov). Nomenclature for genes, alleles, and strains is integrated with data held in other Mouse Genome Informatics resources (http://www.informatics.jax.org), so that users have access, via hypertext links, to a wide range of additional genetic and phenotypic information.

MTB is supported by NCI grant CA89713.

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