International Mammalian Genome Society

logo18th International Mouse Genome Conference

17-22 October 2004, Seattle, USA


POSTER 186 - MOUSE MODELS OF HUMAN DISEASE:  THE INDUCED MUTANT RESOURCE AND MOUSE REPOSITORY AT THE JACKSON LABORATORY

Lane DB, Lutz CM, Rockwood SF, Linder CC, Davisson MT

The Jackson Laboratory, Bar Harbor, United States

Targeted mutation and transgenic mutant mouse models serve as invaluable research tools to study human disease.  Recent advances in mouse genome manipulation and the information generated by the human and mouse genome projects have led to increased development and use of induced mutant mouse models.  As the number of mutant mouse strains grows, cooperative accessible resources for these research tools are needed. 

The Induced Mutant Resource (IMR) at The Jackson Laboratory imports, preserves and distributes mouse strains important for biomedical research.  The IMR serves as a resource through which researchers can provide their strains to the rest of the scientific community.  Cryopreservation of each IMR strain ensures protection of genetic integrity and its continued availability in the future.  An online database of curated strain information is maintained as a resource for researchers. Mutant strain records in the IMR database include phenotype descriptions, transgene or targeted mutation information, strain development and maintenance procedures, references, and links to other relevant online resources. Currently the IMR contains over 1000 accepted strains and adds approximately 5-6 strains each month. Over 130,000 mice are distributed each year from the IMR.  Newly acquired strains include Alzheimer's Disease related models, mouse models for Spinal Muscular Atrophy and a conditional mutation strain for multiple endocrine neoplasia type 1.

Researchers can submit candidate strains directly through forms available on The Jackson Laboratory website at: http://www.jax.org/resources/submit_strain.html.

The IMR is part of a centralized repository that also includes spontaneous mutation strains and strains valuable for genetic analysis of complex traits.

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