International Mammalian Genome Society

logo18th International Mouse Genome Conference

17-22 October 2004, Seattle, USA


ORAL PRESENTATION

WEDNESDAY OCTOBER 20

11.15am – 11.30am

REQUIREMENT OF DELTA1 DURING EARLY NEUROGENESIS IN MICE

Przemeck G1, Wünsch K1, Gossler A2, Hrabé de Angelis M1

1 GSF- National Research Center, Institute of Experimental Genetics, Neuherberg/Munich, Germany, 2 Institute of Molecular Biology OE5250, Medizinische Hochschule Hannover, Hannover, Germany

During vertebrate neurogenesis, several Notch ligands and receptors are expressed in distinct as well as overlapping domains suggesting specific functions for and combinatorial interactions between ligands and receptors of the Delta/Notch signal transduction pathway. Lateral inhibition mediated by Notch signaling is required in the central nervous system (CNS) for maintaining neuroepithelial progenitors and their coordinate differentiation into neuronal precursors. Here, we present data on the neuronal phenotype of mouse embryos carrying a null mutation of the Notch ligand Delta1 (Dll1). Whereas various populations of neuronal progenitor cells formed prematurely several specific differentiated cell types are reduced or lost. Together, our findings identify Delta1 as a critical regulator of early neurogenesis in mice and demonstrate different requirements for Delta1 signals in different parts of the nervous system.

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