International Mammalian Genome Society

logo18th International Mouse Genome Conference

17-22 October 2004, Seattle, USA


Reddy TBK, Blake JA, Bult CJ, Ringwald M, Richardson JE, Kadin JA, Eppig JT

The Jackson Laboratory, Bar Harbor, United States

The Mouse Genome Informatics (MGI) system provides an integrated and curated resource for information about the laboratory mouse. MGI represents extensive primary experimental data sets and also provides a consensus view of the biology of the laboratory mouse. All data associations are supported with evidence and citations. From genotype to phenotype, this resource integrates information about sequences, maps, gene function, expression analyses, alleles, strains and mutant phenotypes. Comparative mammalian data are also presented in the form of comparative maps and mammalian orthology relations.

MGI acquires data by direct data loads from other databases, from labs that generate data and from published literature. The indexing and nomenclature process ensures proper association of a publication with genes and mutant phenotypes described and ensure the use of standard nomenclature. We co-curate data with NCBI, SWISSPROT and other resources to ensure proper Sequence to Gene Marker associations. MGI makes use of several controlled vocabularies as tools for grouping and querying the various datasets comprising the database. The GO annotation system is used to describe a gene product in terms of the function it performs, the process that the function is part of, and the cellular compartment or complex in which it is found. The mammalian Phenotype Ontology is being developed and applied to describe phenotypes of mutant and genetically engineered mice. The mouse anatomical dictionaries are used to consistently annotate expression data, clone libraries and phenotypes.

The combined efforts at MGI produce a community resource for researchers, providing information on official nomenclature for genes/strains, extensive gene characterization, comparative mapping of orthologus genes in other mammals, mouse gene expression data, mouse tumor biology data, sequence to gene associations, strain polymorphisms, mutant allele and phenotype descriptions. Various reports are provided through the ftp server for computational users. These concerted efforts to integrate mouse genome data with mouse biology make the MGI resource unique and support the use of mouse as a model for human disease and biology.

MGI is supported by grants HG00330 and HG02273 from NHGRI, HD33745 from NICHD and CA89713 from NCI.

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