International Mammalian Genome Society

logo18th International Mouse Genome Conference

17-22 October 2004, Seattle, USA


POSTER 5 - HUMOT (HUMAN AND MOUSE ORTHOLOGOUS ANNOTATION): NAMING OF ORTHOLOGOUS GENES FROM THE HUMAN AND MOUSE TRANSCRIPTOME PROJECTS

Maltais LJ 1, Blake JA 1, Bult CJ 1, Wright MW 2, Wain H 2, Povey S 2, Eppig JT 1

1 The Jackson Laboratory, Bar Harbor, ME, United States, 2 University College London, London, United Kingdom

Identifying all full length mRNA transcripts in both mouse and human through international collaborative efforts is generating an abundance of data. The RIKEN mouse cDNA sets of 60,000 clones, representing 21,000 unique mouse genes and the 42,000 annotated human cDNAs from the Odaiba H-Invitational, represent approximately 23,000 unique human genes. These large cDNA sets provide an opportunity to assign nomenclature to those genes which do not have, as yet,  meaningful symbols and names.  Both the RIKEN set and the Odaiba set are already annotated with data suggesting function, or sequence similarity with other species.  The Mouse Genomic Nomenclature Committee (MGNC) and the HUGO Gene Nomenclature Committee (HGNC), with a long history of working together to provide standardized nomenclature for orthologous genes, will utilize these mouse and human annotated cDNA sets to rapidly identify and name orthologous genes. To date there are approximately 19,000 known genes in both species, which have a meaningful and standardized nomenclature assigned to them. These have been named primarily based on data from the scientific literature, author submissions, and databases, such as, EntrezGene, SwissProt, and other organism orthologs. There is a community need, in both mouse and human, to have the remaining unnamed genes identified and their relationships to genes in other species established. HUMOT will fulfill this need.

Supported by NIH HG00330 and Welcome Trust 072955

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